摘要
盐诱导激酶是一种丝氨酸/苏氨酸蛋白激酶,在能量代谢、细胞信号转导、细胞周期、肿瘤、黑素原生成等诸多方面发挥重要作用。目前大量研究表明,抑郁症、睡眠障碍、癫痫、脑卒中等疾病的发生发展与盐诱导激酶密切相关。本文将重点阐述盐诱导激酶与神经精神系统疾病相关性的研究进展。
Salt-inducible kinase(SIK)is a serine/threonine protein kinase.It has been confirmed that SIK plays an important role in energy metabolism,cell signal transduction,cell cycle,tumor,melanogenesis and many other aspects.At present,a large number of studies have shown that the occurrence and development of depression,sleep disorders,epilepsy,stroke and other diseases are closely related to SIK.This article will focus on the research progress of the correlation between SIK and neuropsychiatric diseases.
作者
李溪
张彦可
LI Xi;ZHANG Yanke(Clinical Medicine School of Jining Medical College,Jining,Shandong 272000,China;不详)
出处
《中国临床研究》
CAS
2023年第5期730-733,共4页
Chinese Journal of Clinical Research
基金
国家自然科学基金(81901324)
济宁市重点研发计划项目(2021YXNS057)。
关键词
盐诱导激酶
昼夜节律
抑郁症
癫痫
脑卒中
Salt-inducible kinase
Circadian rhythm
Depression
Epilepsy
Stroke
