摘要
目的探讨急性缺血性卒中(AIS)合并血脂代谢异常患者血清载脂蛋白B100(ApoB100)、低密度脂蛋白受体(LDLR)、前蛋白转化酶枯草溶菌素-9(PCSK-9)水平与病因和神经功能缺损程度的关系。方法选取2018年7月至2020年4月在该院住院的AIS合并血脂代谢异常患者60例作为AIS组,另选取同期体检中心的健康人群60例作为对照组。检测两组血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、ApoB100、LDLR及PCSK-9水平并进行比较。采用急性卒中治疗Org10172试验(TOAST)对AIS患者进行病因分型,美国国立卫生研究院卒中量表(NIHSS)评分评估患者神经功能缺损程度,分析AIS患者血清ApoB100、LDLR、PCSK-9水平与NIHSS评分、TOAST病因分型的关系。结果AIS组血清TC、LDL-C水平明显高于对照组,HDL-C水平明显低于对照组(P<0.05),两组血清TG水平无明显差异(P>0.05)。AIS组血清ApoB100、LDLR、PCSK-9水平均明显高于对照组(P<0.05)。不同TOAST分型患者血清Apo B100、LDLR水平无明显差异(P/>0.05),血清PCSK-9水平有明显差异(P<0.05)。不同神经功能缺损程度的AIS患者血清ApoB100水平无明显差异(P>0.05),LDLR、PCSK-9水平有明显差异(P<0.05)。NIHSS评分与血清ApoB100水平无明显相关性(r=0.650,P=0.114),与血清LDLR、PSCK-9水平均呈正相关(r=0.844,P=0.001;r=0.665,P=0.018)。结论AIS合并血脂代谢异常患者血清ApoB100、LDLR及PCSK-9水平升高,且血清LDLR、PCSK-9水平与患者神经功能缺损程度相关,可能作为早期判断卒中严重程度的生物学标志物。
Objective To investigate the relationship between the serum levels of apolipoprotein B100(ApoB100),low density lipoprotein receptor antibody(LDLR)and recombinant proprotein convertase subtilisin/kexin type 9(PCSK-9)in acute ischemic stroke(AIS)patients complicated with lipid metabolism abnormalities and the etiology of AIS and degree of neurological deficit.Methods From July 2018 to April 2020,a total of 60 AIS inpatients complicated with lipid metabolism abnormalities in this hospital were selected as the AIS group,and 60 healthy individuals who underwent physical examination in the physical examination center of this hospital were selected as the control group.The serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),ApoB100,LDLR and PCSK-9 were detected and compared.The trial of Org 10172 in acute stroke treatment(TOAST)was used to classify the etiology of AIS patients,and the National Institute of Health stroke scale(NIHSS)score was used to evaluate the degree of neurological deficit.The relationships between serum levels of ApoB100,LDLR and PCSK-9 in AIS patients and NIHSS score and TOAST etiology classification were ana-lyzed.Results The serum TC and LDL-C levels in the AIS group were significantly higher than those in the control group,while the serum HDL-C level was significantly lower than that in the control group(P<0.05).There was no significant difference in serum TG level between the two groups(P>0.05).The serum levels of ApoB100,LDLR and PCSK-9 in the AIS group were significantly higher than those in the control group(P<0.05).There was no significant difference in serum ApoB100 and LDLR levels among the patients with different TOAST classification(P>0.05),while there was significant difference in serum PCSK-9 level(P<0.05).There was no significant difference in serum ApoB100 level among the patients with different degree of neurological deficit(P>0.05),while there was significant difference in serum LDLR and PCSK
作者
魏建刚
汪毅明
孙薇
杨建波
张倩
徐金凤
林晓静
王蓉
韩佳容
张小宁
WEI Jiangang;WANG Yiming;SUN Wei;YANG Jianbo;ZHANG Qian;XU Jinfeng;LIN Xiaojing;WANG Rong;HAN Jiarong;ZHANG Xiaoning(The Second Department of Encephalopathy,Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University,Urumqi,Xinjiang 830000,China)
出处
《重庆医学》
CAS
2023年第10期1494-1499,共6页
Chongqing medicine
基金
新疆维吾尔自治区自然科学基金面上项目(2018D01C280)。
