摘要
目的探讨黄芪在目前我国已有中成药中的配伍特点和组方规律。方法以《中华人民共和国药典》《中药成方制剂》为数据来源,运用频次分析、关联规则分析、网络图谱分析挖掘含有黄芪的中成药主治疾病、适用证候、常用药对及配伍规律等。结果收集并整理含有黄芪的中成药570种,共涉及中药624种,药性味以温、甘为主,归经以肝、肾、肺为主。主治疾病155种,主要有虚劳、眩晕等,对应证候149种,其中气血两虚证出现频次最高。通过关联分析得出常见配伍药物包括黄芪、当归,得到核心药物组合16组,关联规则15条。对含有黄芪的中成药配伍网络分析,当支持度≥35%时,呈现出含有黄芪的中成药的核心配伍药物;对含有黄芪的中成药主治疾病药物配伍分析发现,治疗虚劳、眩晕、气血两虚证、肾阳虚证的核心药物均含有当归、黄芪、熟地黄。结论含有黄芪的中成药多以黄芪配伍益气补血、补虚养阴类药物,对于气血两虚、肾阳虚及气阴两虚证类疾病具有突出的治疗作用。
Objective To explore the concerted application characteristics and formulation rules of Astragali Radix in Chinese patent drugs in China at present.Methods Chinese Pharmacopoeia and Traditional Chinese Medicine Prescriptions were used as data sources.Indicative diseases,applicable syndromes,commonly used drug pairs,and concerted application rules of Chinese patent drug containing Astragali Radix were explored by using frequency analysis,association rule analysis,and network atlas analysis.Results Five hundred and seventy kinds of Astragali Radix in Chinese patent drugs were collected and sorted out,involving 624 kinds of traditional Chinese medicines.The drug nature and flavour were mainly warm and sweet,and the channel tropisms were mainly liver,kidney and lung.There were 155 main diseases,mainly including fatigue,dizziness,etc.There were 149 corresponding syndromes,with the highest frequency of syndrome of deficiency of both qi and blood occurring.It was found that common concerted application drugs include Astragali Radix and Angelicae Sinensis Radix through correlation analysis.Sixteen core drug combinations and 15 association rules were obtained.The compatibility network analysis of Chinese patent medicine containing Astragali Radix showed that the core compatibility of Chinese patent medicine containing Astragali Radix showed when the support degree was≥35%.Analysis on the compatibility of Chinese prescription drugs containing Astragali Radix showed that the core drugs for treating consumptive disease,vertigo,syndrome of deficiency of both qi and blood,and syndrome of deficiency of kidney yang all contained Angelicae Sinensis Radix,Astragali Radix and Rehmanniae Radix Praeparata.Conclusion Astragali Radix in Chinese patent drugs is mainly composed of Astragali Radix with drugs of supplementing qi and blood,tonifying deficiency and nourishing yin,which has prominent therapeutic effect on diseases of syndrome of deficiency of both qi and blood,syndrome of deficiency of kidney yang and syndrome of deficiency
作者
李杨
马伟
LI Yang;MA Wei(Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)
出处
《中国医药导报》
CAS
2023年第14期146-150,共5页
China Medical Herald
基金
黑龙江省博士后资助经费项目(LBH-Z20199)。
关键词
黄芪
中成药
配伍规律
数据挖掘
关联分析
Astragali Radix
Chinese patent drugs
Concerted application rule
Data mining
Association analysis
