摘要
目的比较卡格列净和二甲双胍在2型糖尿病(T2DM)合并轻度阻塞性睡眠呼吸暂停综合征(OSAHS)中的应用效果。方法选取2020年6月至2021年6月广西壮族自治区百色市人民医院收治的60例T2DM合并轻度OSAHS患者,根据随机数字表法将其分为卡格列净组和二甲双胍组,每组30例。卡格列净组口服卡格列净,二甲双胍组口服二甲双胍,均治疗12周。比较两组治疗前后血糖指标、血脂指标、体重指数(BMI)、血压、通气功能和治疗期间不良反应发生情况。结果治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数均低于治疗前,差异有统计学意义(P<0.05),但两组组间比较,差异无统计学意义(P>0.05)。治疗后,两组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均低于治疗前,高密度脂蛋白胆固醇(HDL-C)高于治疗前,且卡格列净组TC、TG、LDL-C低于二甲双胍组,HDL-C高于二甲双胍组,差异有统计学意义(P<0.05)。治疗后,卡格列净组BMI、收缩压、舒张压、呼吸紊乱指数(AHI)低于治疗前,最低经皮动脉血氧饱和度(LSpO_(2))高于治疗前,且卡格列净组BMI、收缩压、舒张压、AHI低于二甲双胍组,LSpO_(2)高于二甲双胍组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论与二甲双胍比较,卡格列净不仅有效改善T2DM合并轻度OSAHS患者血糖、血脂水平,还能有效改善血压、通气功能和减轻体重。
Objective To compare the effects of Canagliflozin and Metformin in type 2 diabetes mellitus(T2DM)combined with mild obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Sixty patients with T2DM complicated with mild OSAHS admitted to Baise People’s Hospital of Guangxi Zhuang Autonomous Region from June 2020 to June 2021,according to random number table method,they were divided into Canagliflozin group and Metformin group,with 30 cases in each group.Canagliflozin group received Canagliflozin orally and Metformin group received Metformin orally,all were treated for 12 weeks.Blood glucose index,blood lipid index,body mass index(BMI),blood pressure,ventilation function,and the occurrence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,and insulin resistance index of the two groups were lower than before treatment,the differences were statistically significant(P<0.05),but there was no statistical significance between the two groups(P>0.05).After treatment,total cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL-C)in both groups were lower than before treatment,while high density lipoprotein cholesterol(HDL-C)was higher than before treatment,and TC,TG,and LDL-C in Canagliflozin group were lower than those in Metformin group,while HDL-C was higher than those in Metformin group.After treatment,BMI,systolic blood pressure,diastolic blood pressure,and apnea hypopnea index(AHI)in Canagliflozin group were lower than before treatment,and lowest percutaneous arterial oxygen saturation(LSpO_(2))was higher than before treatment,and BMI,systolic blood pressure,diastolic blood pressure,and AHI in Canagliflozin group were lower than those in Metformin group,while LSpO_(2)was higher than those in Metformin group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two group
作者
杨斌
余飞
王勇
潘美时
林之源
YANG Bin;YU Fei;WANG Yong;PAN Meishi;LIN Zhiyuan(Department of Endocrinology,Baise People’s Hospital,Guangxi Zhuang Autonomous Region,Baise533000,China;Reproductive Medicine Center,Baise People’s Hospital,Guangxi Zhuang Autonomous Region,Baise533000,China)
出处
《中国医药导报》
CAS
2023年第14期118-122,共5页
China Medical Herald
基金
广西壮族自治区卫生健康委员会自筹经费科研项目(Z20201413)。
