摘要
儿童肥胖的患病率正在逐渐增加,在世界范围内女童的肥胖患病率为5.6%,男童为7.8%。这同时导致肥胖相关疾病发病率也相应增加,尤其是阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)。肥胖是儿童OSA的独立危险因素和调节因子。儿童OSA和肥胖之间存在一种双向因果关系。在儿童OSA和肥胖之间的联系中,涉及的因素包括炎症反应、氧化应激和肠道菌群等。然而,肥胖相关的炎症反应与OSA发病机制之间的因果关系仍需进一步研究,本综述就儿童肥胖与OSA的相关性进行探讨。
Prevalence of childhood obesity is progressively increasing,reaching worldwide levels of 5.6%in girls and of 7.8%in boys.This also leads to a corresponding increase in the prevalence of obesity-associated morbidities particularly those involving obstructive sleep apnea(OSA).Obesity is an independent risk factor and regulator of OSA in children.There is a bidirectional causal relationship between OSA and obesity in children.The factors involved in the association between OSA and obesity are systemic inflammation,oxidative stress,and gut microbiota etc.However,a causal link between obesity-related inflammatory state and OSA pathogenesis still needs to be properly confirmed.The present review aimed to investigate the links between childhood obesity and OSA.
作者
李晶
杨屈扬
许莹
韩富根
赵靖
LI Jing;YANG Quyang;XU Ying;HAN Fugen;ZHAO Jing(Department of Otolaryngology Head and Neck Surgery,Children's Hospital Affiliated of Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,450000,China;Department of Otolaryngology Head and Neck Surgery,Beijing Children's Hospital,Capital Medical University,National Children's Medical Center)
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2023年第4期318-322,共5页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
河南省医学科技攻关计划联合共建项目(No:LHGJ20200656)
国家呼吸系统疾病临床医学研究中心呼吸专项(No:HXZX-20210201)
北京市医院管理中心“登峰”计划专项经费资助(No:DFL20191201)。
