摘要
目的探讨60岁及以上老年女性2型糖尿病(T2DM)患者25羟维生素D[25(OH)D]对血脂异常的影响。方法回顾分析北京市垂杨柳医院2020年1—12月收治住院的175例符合纳入标准的老年T2DM女性患者的临床资料,年龄为66(63,70)岁。依据血脂异常诊断标准(胆固醇≥6.2 mmol/L或高密度脂蛋白胆固醇<1.0 mmol/L或低密度脂蛋白胆固醇≥4.1 mmol/L或三酰甘油≥2.3 mmol/L)分为血脂异常组110例(62.9%)和血脂正常组65例(37.1%)。二元Logistic回归分析血脂异常的影响因素,通过Spearman相关性分析了解血清25(OH)D与血脂指标间的关系。结果175例患者血清25(OH)D水平为10.92(8.1,15.2)μg/L。血脂异常组血清25(OH)D的,水平为9.1(5.8,12.9)μg/L,低于血脂正常组的11.9(8.4,22.6)μg/L;血脂异常组合并高血压的比例和体质指数、腰围、同型半胱氨酸水平高于血脂正常组(均P<0.05)。多因素Logistic回归分析结果显示,合并高血压、采腰围、同型半胱氨酸水平是老年T2DM女性患者血脂异常的重要危险因素,血清25(OH)D是老年T2DM女性患者血脂异常的保护因素(P<0.05)。相关分析结果显示,25(OH)D与胆固醇、低密度脂蛋白胆固醇呈负相关(均P<0.05),与高密度脂蛋白胆固醇呈正相关(P<0.05)。结论老年女性T2DM患者血清25(OH)D缺乏较严重,25(OH)D是老年女性T2DM患者血脂异常的保护因素,临床医生在诊疗中应关注患者的维生素D缺乏并积极纠正治疗。
Objective To evaluate the influence of 25-hydroxyvitamin D[25(OH)D]on dyslipidemia in elderly female patients with type 2 diabetes(T2DM)mellitus aged 60 or over.Methods We retrospectively reviewed the clinical records of 175 type 2 diabetic older women meeting the inclusion criteria,admitted to the Department of Endocrinology,Beijing Chuiyangliu Hospital,between January and December 2020,with an average age of 66(63,70)years.According to the diagnostic criteria of dyslipidemia(cholesterol≥6.2 mmol/L,high density lipoprotein cholesterol<1.0 mmol/L,low-density lipoprotein cholesterol≥4.1 mmol/L or triglycerides≥2.3 mmol/L),110 participants(62.9%)were divided into a dyslipidemia group and 65 participants(37.1%)were assigned into a normal blood lipid group.Logistic regression was employed to investigate factors influencing dyslipidemia.Spearman correlation analysis was employed to analyze the correlation between serum 25(OH)D and blood lipid indexes.Results The median serum 25(OH)D level of the 175 subjects was 10.92(8.1,15.2)μg/L.For the dyslipidemia group,it was 9.1(5.8,12.9)μg/L,lower than 11.9(8.4,22.6)μg/L in the normal blood lipid group.The proportion of people with hypertension in the dyslipidemia group was higher than in the normal blood lipid group.The dyslipidemia group also had higher BMI,waist circumference and homocysteine levels(P<0.05).Results of multivariate logistic regression analysis demonstrated that hypertension,waist circumference,and homocysteine were significant risk factors for dyslipidemia in elderly women with T2DM,whereas serum 25(OH)D was a protective factor(P<0.05).Correlation analysis results identified that cholesterol and low density lipoprotein cholesterol were inversely correlated to 25(OH)D while high density lipoprotein cholesterol was positively correlated to it(P<0.05).Conclusions There is a serious deficiency of serum 25(OH)D in older women with T2DM.25(OH)D is protective factor in elderly T2DM women against dyslipidemia.Clinicians should pay attention to vitamin D def
作者
陶静
赵桂君
刘翠平
崔丽梅
严晔华
鞠蕊
Tao Jing;Zhao Guijun;Liu Cuiping;Cui Limei;Yan Yehua;Ju Rui(Department of Endocrinology,Beijing Chuiyangliu Hospital,Beijing 100022,China;Department of Obstetrics and Gynecology,Beijing Chuiyangliu Hospital,Beijing 100022,China;Clinical Trial Institution Office,Beijing Obstetrics and Gynecology Hospital,Capital Medical University·Beijing Maternal and Child Health Care,Beijing 100026,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2023年第5期531-534,共4页
Chinese Journal of Geriatrics
基金
北京市朝阳区科技计划项目 (CYSF1713)。
