摘要
目的:探讨早期食管鳞状细胞癌(鳞癌)短期生存预后的影响因素。方法:回顾性分析9699例早期(Tis~T1N0M0)食管鳞癌患者的临床病理资料,采用Logistic回归分析筛选5 a、1 a生存预后的影响因素。结果:生存期<5 a者2713例(28.0%),<1 a者567例(6.6%)。男性、年龄>65岁、肿瘤长径>5 cm、大体类型为斑块型和糜烂型是5 a和1 a生存的危险因素(P<0.05)。有脉管癌栓是5 a和1 a生存的危险因素,OR(95%CI)分别为2.841(2.051~3.934)、1.767(1.087~2.871);肿瘤家族史阳性则是5 a和1 a生存的保护性因素,OR(95%CI)分别为0.819(0.741~0.906)、0.765(0.635~0.920)。黏膜下层浸润是5 a生存的危险因素,OR(95%CI)为1.259(1.126~1.407);但是1 a生存的保护性因素,OR(95%CI)为0.820(0.677~0.994)。结论:性别、年龄、肿瘤家族史、肿瘤长径、大体类型、浸润程度、脉管癌栓是早期食管鳞癌短期生存的重要影响因素。
Aim:To explore the factors affecting the short-term survival of early esophageal squamous cell carcinoma(ESCC).Methods:Clinicopathological data of 9699 patients with ESCC in Tis-T1N0M0 stage were retrospectively analyzed.Logistic regression was used to analyze the influencing factors of 5-and 1-year survival.Results:There were 2713 cases(28.0%)with survival less than 5 years,and 567 cases(6.6%)less than 1 year.Male,age>65 years,the longest tumor diameter>5 cm,gross types of plaque or erosive type were the risk factors of 5-and 1-year survival(P<0.05).Lymphovascular emboli was the risk factor of both 5-and 1-year survival,OR(95%CI)were 2.841(2.051-3.934)and 1.767(1.087-2.871);while positive family history of tumor was the protective factor,OR(95%CI)were 0.819(0.741-0.906)and 0.765(0.635-0.920).Submucosal layer infiltration was the risk factor of 5-year survival,OR(95%CI)were 1.259(1.126-1.407),but the protective factor of 1-year survival,OR(95%CI)were 0.820(0.677-0.994).Conclusion:Gender,age,tumor family history,the longest tumor diameter,gross type,degree of invasion,and lymphovascular emboli may be the influencing factors of short-term survival of ESCC in Tis-T1N0M0 stage.
作者
孙琳
乔佳欣
杨苗苗
赵学科
李兴嵩
陈亚杰
白合林
马琳琳
谢叶真
尤朵
韩文莉
徐瑞华
胡景峰
宋昕
李吉林
任景丽
周福有
王立东
SUN Lin;QIAO Jiaxin;YANG Miaomiao;ZHAO Xueke;LI Xingsong;CHEN Yajie;BAI Helin;MA Linlin;XIE Yezhen;YOU Duo;HAN Wenli;XU Ruihua;HU Jingfeng;SONG Xin;LI Jilin;REN Jingli;ZHOU Fuyou;WANG Lidong(State Key Laboratory of Esophageal Cancer Prevention and Treatment,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Department of Pathology and Pathophysiology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001;Department of Pathology,Linzhou Esophageal Cancer Hospital,Linzhou,Henan 456592;Department of Pathology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014;Department of Thoracic Surgery,Anyang Tumor Hospital,Anyang,Henan 455000)
出处
《郑州大学学报（医学版）》
CAS
北大核心
2023年第3期302-305,共4页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金重点项目(U1804262)
国家自然科学基金面上项目(81872032)。
关键词
食管鳞状细胞癌
早期癌
预后影响因素
esophageal squamous cell carcinoma
early cancer
influencing factors of prognosis
