摘要
目的:观察尤瑞克林联合丁苯酞治疗重症急性脑梗死的疗效,并探讨其对改善患者血清因子的影响。方法:选择2019年10月至2021年5月佳木斯市中心医院就诊的85例重症急性脑梗死患者,采用随机数字表法分为对照组42例(给予单纯丁苯酞)、观察组43例(给予丁苯酞+尤瑞克林),两组患者均持续治疗4周。比较两组患者治疗前后的简易智力状态检查量表(MMSE)、美国国立卫生研究院脑卒中量表(NIHSS)评分及各项血清因子水平和生存情况。结果:观察组治疗后MMSE评分高于对照组,NIHSS评分低于对照组,观察组治疗后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)水平低于对照组,一氧化氮(NO)、血管内皮生长因子(VEGF)水平高于对照组,观察组生存率高于对照组,死亡率低于对照组,差异均具有统计学意义(P<0.05)。结论:尤瑞克林联合丁苯酞治疗重症急性脑梗死可改善患者的神经功能,纠正相关血清因子水平。
Objective To observe the curative effect of Urinary Kallidinogenase combined with Butylphthalide in the treatment of severe acute cerebral infarction,and to explore its effect on improving serum factors in patients.Methods A total of 85 patients with severe acute cerebral infarction admitted to Jiamusi Central Hospital from October 2019 to May 2021 were selected and divided into a control group(42 patients received Butylphthalide)and an observation group(43 patients received Butylphthalide+Urinary Kallidinogenase)by random number table method.Both groups were treated for 4 weeks.The scores of the mini-mental state examination(MMSE),the National Institutes of Health stroke scale(NIHSS),the levels of serum factors and the survival of the two groups were compared before and after treatment.Results After treatment,MMSE score of the observation group was higher than that of the control group,NIHSS score was lower than that of the control group,and the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and matrix metalloproteinase-9(MMP-9)of the observation group were lower than those of the control group.The levels of nitric oxide(NO)and vascular endothelial growth factor(VEGF)were higher than those of the control group.The survival rate and mortality of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Butylphthalide combined with Urinary Kallidinogenase in the treatment of severe acute cerebral infarction can improve the neurological function of patients and correct the level of related serum factors,and the clinical effect is good.
作者
周翔
林萍
ZHOU Xiang;LIN Ping(Jiamusi Central Hospital,Heilongjiang,Jiamusi 154002)
出处
《深圳中西医结合杂志》
2023年第5期104-106,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
重症急性脑梗死
尤瑞克林
丁苯酞
Severe acute cerebral infarction
Urinary Kallidinogenase
Butylphthalide
