摘要
多肽/聚氨基酸分子由于优异的生物相容性、序列可控性和高生物活性等特点,已经被广泛应用于肿瘤诊疗等生物医学领域.然而,这些分子仍然存在一定的缺陷,如光学性质不佳、半衰期短与清除速率快等.本文简述了通过对多肽/聚氨基酸分子的序列设计、侧链修饰和自组装条件进行调控,赋予其可控的光学性质以用于生物成像,更优异的药代动力学和药效学以获得更好的治疗效果.重点介绍了该领域以及本课题组近期关于多肽/聚氨基酸自组装纳米材料的构筑理念及其在肿瘤诊疗领域的应用研究,并对该领域的挑战和未来发展前景进行了展望.
Owing to the excellent biocompatibility,chemical diversity and sequence dependent bioactivity,peptides/poly(amino acids)have been widely used in biomedical applications,especially in tumor theranostics.However,there are still certain drawback of peptide/poly(amino acid)to overcome for future clinical applications,such as limited optical properties,short half-life and fast clearance rate.In this feature article,we describe the sequence design,side chain modification and self-assembled spatial structure of peptide/poly(amino acid).Such factors endow them with additional optical properties and enhanced pharmacokinetic,pharmacodynamic and immunological properties.We focus on the applications of biomaterials self-assembled from peptides/poly-(amino acids)in the aspect of tumor diagnosis and treatment.Additionally,we propose important challenges and future prospects of peptide/poly(amino acid)-based biomaterials for tumor diagnosis and treatment.
作者
滕润鑫
范震
杜建忠
Run-xin Teng;Zhen Fan;Jian-zhong Du(Department of Polymeric Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804)
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2023年第6期853-869,共17页
Acta Polymerica Sinica
关键词
多肽
聚氨基酸
自组装
肿瘤诊疗
Peptide
Poly(amino acid)
Self-assembly
Tumor theranostics
