摘要
目的对偏头痛患者应用阿司匹林与尼莫地平的临床疗效进行比较。方法方便选择2019年1—12月期间在聊城市退役军人医院就诊的86例偏头痛患者作为研究对象。按照随机数表法分组,对照组(43例)使用尼莫地平治疗,研究组(43例)使用阿司匹林治疗。比较两组临床疗效、偏头痛发作情况、血管因子、实验室指标、药物相关不良反应。结果研究组临床疗效高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组疼痛情况以及偏头痛发作次数比对照组均更优,差异有统计学意义(P<0.05)。治疗前,两组患者血浆内皮素(ET)、一氧化氮(NO)比较,差异无统计学意义(P>0.05)。治疗后,两组ET水平比治疗前降低,NO水平比治疗前升高,且研究组ET水平比对照组低,NO水平比对照组高,差异有统计学意义(P<0.05)。治疗前,两组实验室指标核转录因子-κB(NF-κB)、环氧化酶-2(cycloxygenase-2,COX-2)水平比较,差异无统计学意义(P>0.05)。治疗后,研究组NF-κB(6.34±1.02)μg/L、COX-2(4.36±1.02)μg/L低于对照组(10.25±1.03)μg/L、(8.36±1.21)μg/L,差异有统计学意义(t=17.688、16.574、P<0.05)。研究组与对照组药物相关不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿司匹林治疗偏头痛的效果比尼莫地平好,是更加理想的药物。
Objective To compare the clinical efficacy of aspirin and nimodipine in migraine patients.Methods A total of eighty-six migraine patients treated in Liaocheng Veterans Hospital from January to December 2019 were conveniently selected as the study subjects.The control group(43 cases)was treated with nimodipine,and the study group(43 cases)was treated with aspirin.Clinical efficacy,migraine attacks,vascular factors,laboratory indicators,drugrelated adverse reactions were compared between the two groups.Results The clinical efficacy of the research group is higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,pain and migraine attacks in both groups were significantly improved compared with the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the endothelin(ET)and nitric oxide(NO)between the two groups(P>0.05).After treatment,the ET level of the two groups was lower than before treatment,while the NO level was higher than before treatment,and the ET level of the study group was lower than that of the control group,while the NO level was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of nuclear factor-κB(NF-κB)and cycloxygenase-2(COX-2)between the two groups(P>0.05).After treatment,NF-κB(6.34±1.02)μg/L and COX-2(4.36±1.02)μg/L in the study group were lower than those in the control group(10.25±1.03)μg/L and(8.36±1.21)μg/L,and the difference was statistically significant(t=17.688,16.574,P<0.05).There was no significant difference in the incidence of drug-related adverse reactions between the study group and the control group(P>0.05).Conclusion Aspirin works better than nimodipine for migraine,making it a more desirable drug.
作者
黄振坤
陶金霞
于辉
宓连芳
HUANG Zhenkun;TAO Jinxia;YU Hui;MI Lianfang(Department of Neurology,Liaocheng Veterans Hospital,Liaocheng,Shandong Province,252000 China)
出处
《中外医疗》
2023年第8期94-97,102,共5页
China & Foreign Medical Treatment
关键词
偏头痛
阿司匹林
尼莫地平
疗效
血管因子
实验室指标
不良反应
Migraine
Aspirin
Nimodipine
Curative effect
Vascular factor
Laboratory index
Adverse reaction
