摘要
目的 探究哮喘伴肺炎支原体感染患儿应用丙酸氟替卡松联合阿奇霉素序贯疗法治疗的临床效果。方法 方便选取2020年2月—2021年11月济南市儿童医院收治的78例哮喘伴肺炎支原体感染患儿为研究对象,随机分为2组,每组39例。两组患儿均开展哮喘基础治疗,对照组患儿在此基础上予以红霉素肠溶胶囊治疗,研究组患儿予以丙酸氟替卡松吸入气雾剂联合阿奇霉素序贯疗法治疗。比较两组治疗前后嗜酸性粒细胞(EOS)计数、白细胞(WBC)计数、25羟维生素D[25(OH)D]、γ-干扰素(IFN-γ)、免疫球蛋白E(IgE)及视黄醇结合蛋白(RBP)水平,并观察两组患儿肺部哮鸣音消失、气促缓解、咳嗽消失时间及治疗总有效率。结果治疗后,研究组患儿的EOS与WBC计数均低于对照组,差异有统计学意义(t=6.870、4.340,P<0.05)。治疗后,研究组患儿的25(OH)D、RBP水平高于对照组,差异有统计学意义(t=4.657、7.679,P<0.05),IFN-γ、IgE水平低于对照组,差异有统计学意义(t=10.806、16.627,P<0.05)。研究组患儿的肺部哮鸣音消失时间(3.06±0.76)d、气促缓解时间(2.79±0.68)d及咳嗽消失时间(3.35±0.84)d均短于对照组[(5.12±1.14)、(4.51±1.02)、(5.47±1.23)d],差异有统计学意义(t=9.390、8.762、8.889,P<0.05)。研究组患儿的治疗总有效为97.44%,明显高于对照组的79.49%,差异有统计学意义(χ^(2)=4.522,P<0.05)。结论 哮喘伴肺炎支原体感染患儿应用丙酸氟替卡松联合阿奇霉素序贯疗法治疗的效果显著,可有效减轻哮喘气道炎症,缓解临床症状,加速患儿康复。
Objective To explore the clinical effect of sequential therapy of fluticasone propionate combined with azithromycin in children with asthma and mycoplasma pneumoniae infection.Methods 78 children with asthma and mycoplasma pneumoniae infection admitted to Jinan Children's Hospital from February 2020 to November 2021 were conveniently selected as the research subjects and randomly divided into two groups,with 39 cases in each group.Both groups of children received basic treatment for asthma,while the control group received erythromycin enteric coated capsules on this basis.The study group received fluticasone propionate inhalation aerosol combined with azithromycin sequential therapy.Compared the eosinophil(EOS)count,white blood cell(WBC)count,25 hydroxyvitamin D[25(OH)D],interferon-γ(IFN-γ),immunoglobulin E(IgE),and retinol binding protein(RBP)levels between the two groups before and after treatment,and observe the disappearance of lung wheezing,the time to relieve shortness of breath,the time to cough disappearance,and the total effective rate of treatment in the two groups of children.Results After treatment,the EOS and WBC counts of the study group were lower than those of the control group,the differences was statistically significant(t=6.870,4.340,P<0.05).After treatment,the levels of 25(OH)D and RBP in the study group were higher than those in the control group,the differences was statistically significant(t=4.657,7.679,P<0.05).IFN-γand IgE levels were lower than those in the control group,and the difference was statistically significant(t=10.806,16.627,P<0.05).The disappearance time of lung wheezing sounds(3.06±0.76)d,the relief time of shortness of breath(2.79±0.68)d,and the disappearance time of cough(3.35±0.84)d in the study group were shorter than those in the control group(5.12±1.14)d,(4.51±1.02)d,and(5.47±1.23)d,the differences was statistically significant(t=9.390,8.762,8.889,P<0.05).The total effective rate of treatment for children in the study group was 97.44%,significantly higher than 7
作者
靳倩
董传婷
郭辉
JIN Qian;DONG Chuanting;GUO Hui(Department of Pharmacy,Jinan Children's Hospital,Jinan,Shandong Province,250022 China)
出处
《中外医疗》
2023年第7期153-156,161,共5页
China & Foreign Medical Treatment
关键词
丙酸氟替卡松
阿奇霉素
序贯疗法
哮喘
肺炎支原体感染
Fluticasone propionate
Azithromycin
Sequential therapy
Asthma
Mycoplasma pneumoniae infection
