摘要
目的观察血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)的水平变化,分析非酒精性脂肪性肝病(NAFLD)患者发生肝纤维化的可能性。方法86例NAFLD患者,根据影像学检查结果分为无肝纤维化组(59例)、肝纤维化组(27例)。比较两组患者血清ALT、AST及肝纤维化指标[透明质酸酶(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)]水平,采用二元Logistic回归模型分析NAFLD患者肝纤维化的影响因素,采用Pearson相关分析NAFLD患者血清ALT、AST与肝纤维化的相关性。结果肝纤维化组患者血清FBG、ALT、AST、HA、LN、PCⅢ水平分别为(6.41±1.02)mmol/L、(93.64±10.21)U/L、(61.59±5.23)U/L、(94.64±10.25)ng/ml、(110.79±11.82)ng/ml、(119.24±12.72)ng/ml,均明显高于无肝纤维化组的(5.69±0.97)mmol/L、(71.99±10.39)U/L、(50.68±5.51)U/L、(81.04±6.01)ng/ml、(85.62±8.61)ng/ml、(91.61±10.06)ng/ml,差异具有统计学意义(P<0.05)。两组患者血清TC、LDL-C、TG水平比较差异无统计学意义(P>0.05)。二元Logistic回归分析显示:血清ALT、AST水平是NAFLD患者肝纤维化的影响因素(P<0.05)。Pearson相关分析显示:NAFLD患者血清ALT、AST水平与LN、PCⅢ均呈明显正相关(P<0.05),但与HA水平无明显相关性(P>0.05)。结论血清ALT、AST是NAFLD患者出现肝纤维化的影响因素,且NAFLD患者血清中ALT、AST水平与肝纤维化指标LN、PCⅢ均呈明显正相关,通过检测ALT、AST水平可以评估NAFLD患者是否有肝纤维化发生。
Objective To analyze the possibility of hepatic fibrosis in patients with non-alcoholic fatty liver disease(NAFLD)by observing the changes of serum alanine aminotransferase(ALT)and aspartate transaminase(AST)levels.Methods A total of 86 patients with NAFLD were divided into non-hepatic fibrosis group(59 patients)and hepatic fibrosis group(27 patients)according to results of imaging findings.The levels of serum ALT,AST and hepatic fibrosis indexes[hyaluronidase(HA),laminin(LN),type Ⅲ precollagen(PCⅢ)]were compared between the two groups,and the influential factors of hepatic fibrosis in NAFLD patients were analyzed by binary Logistic regression model.Pearson correlation was used to analyze the correlation between serum ALT,AST and hepatic fibrosis in NAFLD patients.Results The serum levels of FBG,ALT,AST,HA,LN and PCⅢ in hepatic fibrosis group were(6.41±1.02)mmol/L,(93.64±10.21)U/L,(61.59±5.23)U/L,(94.64±10.25)ng/ml,(110.79±11.82)ng/ml and(119.24±12.72)ng/ml,which were significantly higher than those of(5.69±0.97)mmol/L,(71.99±10.39)U/L,(50.68±5.51)U/L,(81.04±6.01)ng/ml,(85.62±8.61)ng/ml and(91.61±10.06)ng/ml in the non-fibrosis group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in serum TC,LDL-C and TG levels between the two groups(P>0.05).Binary Logistic regression analysis showed that serum ALT and AST levels were the influencing factors of hepatic fibrosis in NAFLD patients(P<0.05).Pearson correlation analysis showed that serum ALT and AST levels in NAFLD patients were significantly positively correlated with LN and PCⅢ(P<0.05),but had no significant correlation with HA level(P>0.05).Conclusion Serum ALT and AST are influencing factors of hepatic fibrosis in patients with NAFLD,and serum ALT and AST levels in patients with NAFLD are positively correlated with hepatic fibrosis indexes LN and PCⅢ.The detection of ALT and AST levels can be used to assess whether there is hepatic fibrosis in patients with NAFLD.
作者
王艳红
WANG Yan-hong(Department of Clinical Laboratory,Jinzhou District Hospital of Traditional Chinese Medicine,Dalian 116000,China)
出处
《中国现代药物应用》
2023年第9期15-18,共4页
Chinese Journal of Modern Drug Application
