摘要
急性肺损伤是新生儿中常见的一种危急重症,铁死亡作为一种新型细胞程序性死亡形式,可通过调节铁稳态、氨基酸代谢和脂质过氧化反应参与急性肺损伤的进程。深入研究铁死亡在急性肺损伤中的作用机制可为其防治提供新思路。
Acute lung injury is a common critical illness in neonates.Ferroptosis,a novel form of programmed cell death,plays an important role in the process of acute lung injury by regulating iron homeostasis,metabolism of amino acid and lipid peroxidation.In-depth study of the mechanism of ferroptosis in acute lung injury may provide new ideas for its prevention and treatment.
作者
楚晓云
蔡成
CHU Xiaoyun;CAI Cheng(Department of Neonatology,Shanghai Children s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China)
出处
《基础医学与临床》
2023年第6期1008-1011,共4页
Basic and Clinical Medicine
基金
上海市儿童医院院级课题国家自然科学基金培育专项(2020YGZQ01)。
关键词
铁死亡
铁稳态
氨基酸代谢
脂质过氧化
新生儿急性肺损伤
ferroptosis
iron homeostasis
metabolism of amino acid
lipid peroxidation
acute lung injury in neonate
