摘要
目的研究甲状腺乳头状癌(PTC)患者BRAF^(V600E)突变与超声特征的相关性。方法回顾性分析2020年10月—2022年8月共131例经术后病理证实为PTC患者。统计PTC患者BRAF^(V600E)突变的发生率。采用单因素和多因素分析评估BRAF^(V600E)突变与超声特征之间的关系。结果61.8%(81/131)的PTC患者存在BRAF^(V600E)突变。极低回声(OR:7.323,P=0.003)、多灶性(OR:2.911,P=0.024)、微小钙化(OR:4.244,P=0.006)和淋巴结转移(OR:4.524,P=0.004)是BRAF^(V600E)突变的独立预测因素。结论BRAF^(V600E)突变在PTC患者中常见,PTC超声特征包括极低回声、多灶性、微小钙化、以及淋巴结转移与BRAF^(V600E)突变之间存在明显的相关性。
Objective To investigate the incidence of BRAF^(V600E) mutation in patients with papillary thyroid carcinoma(PTC),and analyze the association between BRAF^(V600E) mutation and ultrasonographic features.Methods A total of 131 patients with PTC confirmed by postoperative pathology from October 2020 to August 2022 were retrospectively analyzed.The incidence of the BRAF^(V600E) mutation was calculated.Univariate and multivariate analysis were performed to evaluate the association between BRAF^(V600E) mutation and ultrasonographic features.Results The BRAF^(V600E) mutation was observed in 61.8%(81/131)of PTC.Marked hypoechogenicity(OR:7.323,P=0.003),multifocality(OR:2.911,P=0.024),microcalcification(OR:4.244,P=0.006)and lymph node metastasis(OR:4.524,P=0.004)on ultrasonographic were independent predictive factors for the BRAF^(V600E) mutation.Conclusion BRAF^(V600E) mutation commonly occurs in patients with PTC.Ultrasonographic features of PTC,including marked hypoechogenicity,multifocality,microcalcification and lymph node metastasis,are significantly correlated with BRAF^(V600E) mutation.
作者
周杨
黄雪春
ZHOU Yang;HUANG Xue-chun(Department of Pathology,2.Department of Ultrasonography,Changzhou Second People's Hospital Affiliated to Nanjing Medical University,Changzhou,Jiangsu,213003,China)
出处
《中国血液流变学杂志》
CAS
2022年第4期632-634,共3页
Chinese Journal of Hemorheology