摘要
肝性脑病不是一个独立疾病,而是在较为严重肝病基础上出现的并发症,若失治误治可致患者死亡。“浊”多在“湿”“痰”“瘀”“虚”的基础上兼夹衍生,是人体亚健康或疾病过程中所产生的一种病理产物。“浊”一旦产生,由微至著,盛极而为“浊毒”。“浊毒”在体内积聚可阻碍气机、阻滞血脉及蒙蔽神窍,是导致肝性脑病典型发作的直接因素,也是决定肝性脑病发展与转归的主导因素。“浊毒致病”是肝性脑病的核心发病机制。在既往研究的基础上,基于“浊毒致病”学说逐层解析了导致肝性脑病复杂临床表现的病理机制,形成了对肝性脑病病因病机的全局性认识。以“浊毒致病”学说为纲领,在中医辨病论治及辨证论治的基础上,采用化浊泄浊解毒的治疗策略,无疑对肝性脑病临床疗效的提高将具有重要的现实意义。
Hepatic encephalopathy is not an independent disease,but a complication of a more serious liver disease.If it is not treated properly,it can lead to death."Turbidity"is mostly derived from"dampness""phlegm""blood stasis"and"deficiency".It is a pathological product produced in the process of human sub-health or disease.Once"Turbidity"is produced,it becomes"Turbidity-toxin"when having accumulated from micro to extreme.The accumulation of"Turbidity-toxin"in the body can block Qi,block blood vessels,and blind the mind.It is not only the direct factor leading to the typical attack of hepatic encephalopathy but also the leading factor determining the development and prognosis of hepatic encephalopathy."Turbidity-toxin pathogenesis"is the core pathogenesis of hepatic encephalopathy.Based on previous studies,the pathogenic theory of"Turbidity-toxin"has analyzed the pathological mechanism leading to the complex clinical manifestations of hepatic encephalopathy layer by layer,forming a comprehensive understanding of the etiology and pathogenesis of hepatic encephalopathy.Taking the"Turbidity-toxin"pathogenic theory as the principle,based on disease differentiation and treatment and syndrome differentiation in traditional Chinese medicine,the treatment strategy of detoxifying,removing turbidity and discharging turbidity has important realistic guiding significance for the effective improvement of the treatment of hepatic encephalopathy.
作者
柏文婕
潘佩佩
石清兰
王娜
王萌
姚春
毛德文
BAI Wenjie;PAN Peipei;SHI Qinglan;WANG Na;WANG Meng;YAO Chun;MAO Dewen(Guangxi University of Chinese Medicine,Nanning 530200,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2023年第5期727-730,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
广西自然科学基金面上项目(2020GXNSFAA297206)
广西自然科学基金面上项目(2020GXNSFAA297205)
国家自然科学基金(82060848)
国家自然科学基金(82060847)。
关键词
肝性脑病
浊毒
病因病机
Hepatic Encephalopathy
Turbidity-toxin
Etiology and Pathogenesis
