摘要
目的 旨在探索久居高原环境的藏族2型糖尿病患者(plateau Tibetan type 2 diabetes mellitus, PTDM)与高原藏族健康对照(plateau Tibetan healthy control, PTHC)静息态功能磁共振成像(resting-state functional magnetic resonance imaging, rs-fMRI)局部功能指标的差异及其与认知功能的关系。材料与方法 本研究纳入53名PTDM患者和51名年龄、性别、教育程度匹配良好的PTHC。收集两组患者的人口学资料、临床检验检查结果、神经心理学测试结果和rs-fMRI数据,将rs-fMRI功能指标低频振幅(amplitudeoflow-frequencyfluctuations,ALFF)、比率低频振幅(fractional amplitude of low-frequency fluctuations, fALFF)进行基于体素间的组间差异比较,探究PTDM和PTHC两组间ALFF、fALFF值的差异脑区,及其与人口学、临床检验检查指标和神经心理学测试结果的相关性。结果 与PTHC组相比,PTDM组ALFF值在双侧小脑Ⅷ区降低(P<0.05,FWE校正),fALFF值在右侧舌回、左侧小脑Ⅰ区降低(P<0.05,FWE校正)。相关分析显示,PTDM组患者左侧小脑Ⅷ区(r=0.376,P=0.006)、右侧小脑Ⅷ区(39,-54,-54)(r=0.411,P=0.002)、右侧小脑Ⅷ区(15,-66,-54)(r=0.377,P=0.005)、右侧舌回fALFF值(r=0.337,P=0.014)与年龄呈正相关;PTDM组患者左侧小脑Ⅷ区ALFF值与低密度胆固醇(r=-0.283,P=0.049)、糖化血红蛋白(r=-0.320,P=0.028)、两小时血糖(r=-0.405,P=0.016)呈负相关;右侧舌回fALFF值与Zung氏焦虑自评量表呈负相关(r=-0.399,P=0.012),左侧小脑Ⅰ区fALFF值与吸烟时间呈正相关(r=0.407,P=0.006),与匹兹堡睡眠质量指数量表(r=-0.327,P=0.033)、抑郁自评量表(r=-0.320,P=0.041)及患者健康问卷得分(r=-0.339,P=0.035)呈负相关。结论 高原藏族T2DM患者rs-fMRI局部功能指标在小脑和右侧舌回减低,并与年龄、血糖指标、神经心理及认知功能相关。探究高原藏族T2DM患者的脑功能变化可以更好地了解与疾病相关的认知功能变化及相关机制。
Objective:To explore the differences in regional activity of resting-state functional magnetic resonance imaging(rs-fMRI)between plateau Tibetan with type 2 diabetes mellitus(T2DM)living in a plateau environment and healthy plateau Tibetan,and their relationship with cognitive function.Materials and Methods:Fifty-three plateau Tibetan with type 2 diabetes mellitus(PTDM)and 51 plateau Tibetan healthy control(PTHC)in the analysis after age and sex matched were included in this study.Demographic,clinical data,neuropsychological test and rs-fMRI data were collected of both groups,and the rs-fMRI functional indexes the amplitude of amplitude of low-frequency fluctuations(ALFF)and fractional amplitude of low-frequency fluctuation(fALFF)were compared between two groups based on voxels to investigate the differences.We investigated the differences in ALFF and fALFF values between PTDM and PTHC groups and their correlation with demographics,clinical data and neuropsychological test results.Results:Compared with the PTHC group,the PTDM group had reduced ALFF values in bilateral cerebellar regionⅧ)and reduced fALFF values in the right lingual gyrus and left cerebellar region I(P<0.05,FWE correction).Correlation analysis showed that the fALFF values of left cerebellar areaⅧ(r=0.376,P=0.006),right cerebellar areaⅧ(39,-54,-54)(r=0.411,P=0.002),right cerebellar areaⅧ(15,-66,-54)(r=0.377,P=0.005)and right lingual gyrus(r=0.337,P=0.014)in the PTDM group were positively correlated with age;in the PTDM group were negatively correlated with low-density cholesterol(r=-0.283,P=0.049),glycated hemoglobin(r=-0.320,P=0.028)and two-hour glucose(r=-0.405,P=0.016).fALFF values of right lingual gyrus in the PTDM group were negatively correlated with Zung's anxiety self-rating scale(r=-0.399,P=0.012);fALFF values of left cerebellar area I in the PTDM group were positively correlated with smoking time(r=0.407,P=0.006),and negatively correlated with Pittsburgh Sleep Quality Index Scale(r=-0.327,P=0.033),Depression Self-Rating Scale(r=-0
作者
何万林
李谨利
冯莉
胡鑫
郭勇跃
何媛媛
李恒演
朱中原
孟金丽
HE Wanlin;LI Jinli;FENG Li;HU Xin;GUO Yongyue;HE Yuanyuan;LI Hengyan;ZHU Zhongyuan;MENG Jinli(Department of Radiology,Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region(Hospital C.T.),Chengdu 610041,China;Department of Radiology,the People's Hospital of Jianyang City,Chengdu 641499,China;Huaxi MR Research Center(HMRRC),West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第5期72-78,122,共8页
Chinese Journal of Magnetic Resonance Imaging
基金
四川省科技计划资助项目(编号:2021YJ0161)
四川省医学科研课题(编号:Q20042)
西藏自治区科学技术厅中央引导地方科学发展资金(编号:XZ202102YD0032C)
西藏自治区人民政府驻成都办事处医院院级重点项目(编号:2021-YJ-2)。
关键词
2型糖尿病
高原藏族
低频振幅
比率低频振幅
功能磁共振成像
type 2 diabetes mellitus
plateau Tibetan
amplitude of low-frequency fluctuations
fractional amplitude of low-frequency fluctuations
resting-state magnetic resonance imaging
