摘要
A photocatalyst-and metal-free radical tandem alkylation/cyclization between 1,6-dienes and redox-active esters has been devel-oped,affording a series of N-aryl pyrrolidine-2-ones in moderate to good yields.The transformation is driven by the formation of an electron-donor-acceptor(EDA)complex and a subsequent single electron transfer(SET)process.This photocatalyst-free protocol features excellent regioselectivity,mild conditions and broad substrate scope,providing a facile access to 3-alkyl-3,4-dimethyl-1-phe-nylpyrrolidin-2-one.
基金
supported by the National Natural Science Foundation of China(22078299 and 22108250)
the Natural Science Foundation,of Zhejiang Province(LY21B060005 and LQ20B06007)
Research project of Zhejiang Provincial Department of Education(Y20840109)。
