摘要
目的:观察银翘散加味联合抗生素治疗儿童急性扁桃体炎风热犯肺证的临床疗效,并探讨其机制。方法:将96例急性扁桃体炎风热犯肺证患儿随机分为对照组和观察组,各48例,对照组予抗生素治疗,观察组予银翘散加味中药颗粒剂联合抗生素治疗,两组疗程均为7 d。观察临床疗效,比较两组中医证候积分及炎症、免疫相关指标[白细胞计数(WBC)、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)、γ干扰素(IFN-γ)]水平的变化情况。结果:(1)最终完成试验并纳入统计者92例,观察组45例,对照组47例。(2)观察组、对照组总有效率分别为95.56%(43/45)、93.62%(44/47);组间临床疗效比较,差异无统计学意义。(3)组间治疗后比较,观察组各主症评分均低于对照组(P<0.05)。组间治疗后比较,观察组咳嗽、大便情况、舌象情况评分均低于对照组(P<0.05)。(4)治疗前后组内比较,观察组各炎症和免疫相关指标水平均明显降低(P<0.05),对照组除IFN-γ外的其余炎症和免疫相关指标水平均明显降低(P<0.05)。组间治疗后比较,观察组SAA、IL-6水平明显低于对照组(P<0.05)。结论:银翘散加味联合抗生素治疗儿童急性扁桃体炎风热犯肺证,可以显著降低SAA、IL-6表达水平,有效减轻炎症反应,改善临床症状及缓解病情。
Objective:To observe the clinical effect of modified Yinqiaosan combined with antibiotics in the treatment of acute tonsillitis in children with wind-heat invading lung syndrome.Method:A total of 96 children with acute tonsillitis of wind-heat invading the lung syndrome were randomized into control group and observation group.The control group was treated with routine antibiotics,and the observation group was treated with modified Yinqiaosan and antibiotics for 7 days.The scores of major symptoms(sore throat,erythmatous throat,dysphagia,erythmatous tonsils and suppuration)and minor symptoms(fever,cough,stool,and tongue)and the levels of inflammation-and immune-related indexes[white blood cell(WBC),C-reactive protein(CRP),serum amyloid A(SAA),interleukin-6(IL-6),and interferon-γ(IFN-γ)]were compared between two groups.Result:The data of 92 children were statistically analyzed:45 in the observation group and 47 cases in the control group.The total clinical effective rate of the observation group was 95.56%,as compared with the 93.62%of the control group.After treatment,the scores of major symptoms in the observation group were lower than those in the control group(P<0.05),and the scores of cough,defecation,and tongue in the observation group were lower than those in the control group(P<0.05).The levels of inflammation-and immune-related indexes after treatment in the observation group were lower than those before treatment(P<0.05).Except IFN-γ,the levels of the inflammation-and immune-related indexes in the control group were lower than those before treatment(P<0.05).After treatment,the levels of SAA and IL-6 in the observation group were lower than those in the control group(P<0.05).Conclusion:Modified Yinqiaosan combined with antibiotics can significantly reduce the expression of SAA and IL-6 in the treatment of children with acute tonsillitis,thereby alleviating inflammation and clinical symptoms and improving prognosis.
作者
乔静华
于琳琳
景晓平
董晓艳
顾明达
QIAO Jinghua;YU Linlin;JING Xiaoping;DONG Xiaoyan;GU Mingda(Children's Hospital of Shanghai,Children's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200062,China;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第11期121-125,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
上海市卫计委中医药科研课题项目(2018LP022)
上海市科委“中医引导项目”(19401931900)
上海市卫健委进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-FWTX-3025]。
关键词
急性扁桃体炎
乳蛾
风热犯肺证
银翘散加味
儿童
acute tonsillitis
tonsillitis
syndrome of wind-heat invading lung
modified Yinqiaosan
children
