摘要
目的研究目前临床工作中使用脉络舒通丸治疗骨外科疾病有效患者的用药方案特征和规律。方法从全国11家三甲医院医院信息系统(Hospital information system,HIS)数据库中提取使用脉络舒通丸治疗骨外科疾病有效的病例共计2083例,描述其临床联合用药品种,并采用Tabu搜索算法建立复杂网络模型,利用矩阵法展示不同子网络间关系。并进行关联规则分析,尝试寻找骨外科疾病的核心处方以及各类药物之间的相关性。结果由子结构提取出脉络舒通丸治疗骨外科疾病的中西医结合治疗方案一组,主要包括:脉络舒通丸、头孢类、肝素类、羟乙基淀粉、强骨胶囊。由矩阵展开图得出的常用联合用药10种,主要包括:苯巴比妥、青霉素类、地塞米松、右旋糖酐、红花注射液、曲马多、胰岛素类、庆大霉素、疏血通注射液。结论除去外科手术常规用药,在使用脉络舒通丸治疗骨外科疾病的过程中可考虑以脉络舒通丸、头孢类、肝素类、羟乙基淀粉、强骨胶囊为用药方案,同时可以考虑联用红花注射液、疏血通注射液等活血中药制剂,预防下肢深静脉血栓形成及缓解肢体肿胀。
Objective To study the characteristics and rules of the medication regimen in the real world using Mailuo Shutong Pills to treat patients with orthopedic surgery diseases.Methods From the hospital information system(HIS)database of 11 tertiary hospitals across the country,a total of 2083 cases of extract the effective cases of using Mailuoshutong pills in the treatment of orthopedic surgery diseases,collect the types of clinical combination drugs,and use the Tabu search algorithm to build the model and use the matrix method Show the relationship between different subnetworks for association rule analysis,try to find the core prescriptions of orthopedic surgery diseases and the correlation between various drugs.Results A group of integrated traditional Chinese and Western medicine treatment programs for Mailuoshutong pills for orthopedic surgery diseases are extracted from the substructure,which mainly include Mailuoshutong pills,cephalosporins,heparins,hydroxyethyl starch,and strong bone capsules.10 commonly used combination drugs derived from the expanded matrix diagram,mainly including:sodium chloride,phenobarbital,penicillins,dexamethasone,dextran,safflower injection,tramadol,insulin,gentamicin,Shuxuetong injection.Conclusion In addition to conventional surgical medications,the use of Mailuo Shutong Pills in the treatment of bone surgery diseases can be combined with Qianggu Capsules,Honghua Injection,Shuxuetong Injection and other traditional Chinese medicine preparations for invigorating the kidney and promoting blood circulation to prevent deep vein thrombosis of the lower extremities and Relieve swelling of limbs.
作者
王旭
成冯静茗
谢雁鸣
王连心
苗雨
Wang Xu;Cheng Fengjingming;Xie Yanming;Wang Lianxin;Miao Yu(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Bejing 100700,China;Wangjing Hospital,China Academy of Chinese Medical Sciences,Bejing 100102,China;School of Statistics,Renmin University of China,Beijing 100872,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第1期387-394,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81973982):“区块链”融合深度学习的中药上市后肾损伤预警模型研究,负责人:王连心
中国中医科学院全国中医药创新骨干人才培养项目(Z0687):中药药物警戒平台构建及中医药创新骨干人才培养,负责人:王连心
中国中医科学院中央级公益性科研院所基本业务费项目(Z0597):真实世界中新农合政策对患者结局指标的中介作用分析,负责人:黎元元。
关键词
脉络舒通丸
骨外科疾病
联合用药
真实世界研究
复杂网络分析
Mailuo Shutong pills
Orthopedic diseases
Medication plan
Real world study
Complex network analysis
