摘要
目的 探究双歧杆菌四联活菌片联合肠内营养治疗老年重症缺血性脑卒中患者消化道并发症及肠黏膜屏障功能的影响。方法 选取河北北方学院附属第二医院收治的110例老年重症缺血性脑卒中患者作为研究对象。2020年1月~2021年1月收治的67例为对照组,给予常规肠内营养治疗,2021年2月~2022年1月收治的43例为观察组,在对照组基础上加用双歧杆菌四联活菌片治疗,两组均连续干预2周。比较两组治疗前后微型营养评定简表(MNA-SF)评分、血红蛋白(Hb)、上臂三头肌肌围(AMC)指标变化、营养状态指标[甘油三酯(TG)、人血白蛋白(ALB)及总胆固醇(TC)]、肠黏膜屏障功能指标(二胺氧化酶及D-乳酸),同时观察两组治疗期间的消化道并发症发生情况。结果 治疗前,两组各指标比较,差异均无统计学意义(P>0.05);治疗后,观察组MNA-SF评分、AMC及Hb、TG、ALB、TC水平高于对照组,二胺氧化酶及D-乳酸水平低于对照组,差异均有统计学意义(P<0.05)。观察组消化道并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论 双歧杆菌四联活菌片联合肠内营养治疗可有效改善老年重症缺血性脑卒患者的营养状态,改善肠黏膜屏障功能,降低消化道并发症的发生率。
Objective To explore the effects of Bifidobacterium tetragenous viable bacteria tablets combined with enteral nutrition on gastrointestinal complications and intestinal mucosal barrier function in older patients with severe ischemic stroke.Methods A total of 110 older patients with severe ischemic stroke admitted to the Second Affiliated Hospital of Hebei North University were enrolled in this study.Among them,67 cases(admitted to hospital from January 2020 to January 2021,received routine enteral nutrition treatment)were assigned to the control group,43 cases(admitted to hospital from February 2021 to January 2022,received routine enteral nutrition treatment and Bifidobacterium tetragenous viable bacteria tablets)were assigned to the observation group.All patients were treated for 2 weeks.The score of Mini Nutritional Assessment Short Form(MNA-SF),level of hemoglobin(Hb),arm muscle circumference(AMC),the levels of triglyceride(TG),serum albumin(ALB),total cholesterol(TC),diamine oxidase and D-lactic acid were compared between the two groups before and after treatment.The occurrence of gastrointestinal complications during treatment was recorded.Results Before treatment,there were no significant differences in all indicators between the two groups(P>0.05).After treatment,the MNA-SF score,AMC,levels of Hb,TG,ALB and TC in the observation group were higher than those in the control group,and the levels of diamine oxidase and D-lactic acid were lower than those in the control group,with statistical significance(P<0.05).The overall incidence of gastrointestinal complications in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Bifidobacterium tetragenous viable bacteria tablets combined with enteral nutrition may effectively improve the nutritional status and intestinal mucosal barrier function of older patients with severe ischemic stroke,and reduce the incidence of gastrointestinal complications.
作者
宋彦丽
唐进松
杨春燕
李文慧
刘敏肖
Song Yanli;Tang Jinsong;Yang Chunyan;Li Wenhui;Liu Minxiao(The Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100)
出处
《国际老年医学杂志》
2023年第3期326-329,共4页
International Journal of Geriatrics
基金
张家口市重点研发计划项目(2021105D)。
关键词
双歧杆菌四联活菌片
肠内营养
缺血性脑卒中
营养状态指标
肠黏膜屏障功能
Bifidobacterium tetragenous viable bacteria tablets
Enteral nutrition
Ischemic stroke
Nutritional status indicators
Intestinal mucosal barrier function