摘要
目的探讨PTBP3与STAT3在胃癌组织中的表达与临床病理因素的关系。方法采用免疫组化染色方法检测100例胃癌组织和癌旁组织中PTBP3、STAT3的表达,分析与临床病理因素之间的关系,并且比较两种蛋白不同表达组间患者的预后。结果PTBP3、STAT3在胃癌组织中表达水平(分别为72%、63%)明显高于癌旁组织(分别为23%、19%),差异具有统计学意义(P<0.05);两者表达与胃癌患者的肿瘤大小、浸润深度、分化程度及淋巴结转移情况关系密切(P<0.05),两者在胃癌组织中表达呈正相关(r=0.306,P<0.05)。两种蛋白阴性表达组的生存率高于阳性组(P<0.05)。结论PTBP3、STAT3蛋白的表达与胃癌的临床病理学特征关系密切,两种蛋白阴性表达组患者预后明显优于阳性表达组。二者的联合检测将有助于胃癌的诊断以及恶性程度和预后的评估。
Objective To explore the expression of PTBP3 and STAT3 in gastric carcinoma And their relationship with clinicopathological features.Methods The expression of PTBP3 and STAT3 was detected in 100 gastric carcinoma and adjacent non-tumorous tissues by the immunohistochemical staining,to view the relationship between two protein expression and clinicopathological features,compare the prognosis of the patients between the different expression groups.Results PTBP3 and STAT3 expression in gastric carcinoma(72%,63%,respectively)were significantly higher than adjacent non-tumorous tssues(23%,19%,respectively)(P<0.05).The expression of PTBP3 and STAT3 significantly correlated with tumor size,depth of tumor invasion,grade of cell differentiation and Lymph node metastasis(P<0.05).The expression of PTBP3 and STAT3 were positively correlated in gastric cancer(r=0.306,P<0.05).The survival rate was higher in the two protein negative expression group than that in the positive group(P<0.05).Conclusion PTBP3 and STAT3 expression significantly correlated with the clinical pathophysiological characteristics in gastric carcinoma.The prognosis of patients in both protein negative expression groups was significantly better than that in the positive expression group.Detection of PTBP3 and STAT3 may be valuable for diagnosing gastric carcinoma and evaluating malignancy extent and prognosis.
作者
李佳
李刚
邢益祥
谢贞兰
赵铁
LI Jia;Li Gang;XING Yi-xiang;XIE Zhen-lan;Zhao Tie(Department of Pathology,The People's Hospital of Tongling,Tongling,Anhui Province 244000,China;Department of Genetics and Eugenics,The NO.4 People's Hospital of Tongling,Tongling,Anhui Province 244000,China)
出处
《解剖学研究》
CAS
2023年第2期133-138,共6页
Anatomy Research
关键词
胃癌
多嘧啶结合蛋白3
信号转导及转录激活因子3
免疫组化染色
Gastric carcinoma
Polypyrimidine tractbinding protein 3(PTBP3)
Signal transducer and activator of transcription(STAT3)
Immunohistochemistry stain
