摘要
目的 了解结核病的发病水平、结核菌耐药情况,为今后制定和实施针对性的防控措施提供参考。方法 分别从国家“结核病信息管理系统”和“婺源县统计局”获取2010年至2021年婺源县分年度的结核病传染病报告卡中个案信息和常住人口学数据,采用固体药敏法对培养阳性的标本开展药敏检测,应用SPSS22.0软件进行统计分析。结果 2010年至2021年,婺源县共报告结核病2 864例,结核病年报告发病率为36/10万~89/10万,呈逐年下降趋势。男性结核病年发病率(52/10万~124/10万)略高于女性(19/10万~52/10万)。2 864例结核患者的平均年龄为(46.41±17.53)岁,职业以“农民/民工”为主(84.22%),病原学诊断“阳性”率为55.69%。2 864例结核病患者根据规范用药方案成功治疗率为91.89%(2 617/2 848)。结核药物敏感性检测显示,结核病整体耐药率为22.55%,多耐药率为10.64%,耐多药率为6.38%。结论 婺源县结核病年报告发病率呈逐年下降趋势,但耐药结核病患者比例较高。今后应提高对男性、高龄居民等重点人群关注,做到重点宣教、重点监测和重点干预,严格落实结核病患者规范治疗,降低结核病发病率和耐药率。
Objective To understand the incidence of tuberculosis and drug resistance of anti-tuberculosis,and to provide reference for the formulation and implementation of targeted prevention and control measures.Methods Case information of tuberculosis report card and resident demographic data in Wuyuan county from 2010 to 2021 were obtained from the National Tuberculosis Information Management System and Wuyuan County Bureau of Statistics,respectively.Solid anti-tuberculosis drug sensitivity was applied to test the drug sensitivity condition among the positive sample,and SPSS22.0 software was used for statistical analysis.Results From 2010 to 2021,a total of 2864 tuberculosis cases were reported in Wuyuan county.The annual reported incidence rate of tuberculosis was between 36/100000 and 89/100000,with a downward trend year by year.The annual incidence rate in male tuberculosis(52/100000-124/100000)was slightly higher than that in female tuberculosis(19/100000-52/100000).The average age of 2864 tuberculosis patients was(46.41±17.53)years old,the occupation was mainly"farmers/migrant workers"(84.22%),and the"positive"rate of pathogenic diagnosis was 55.69%.The successful treatment rate of 2864 tuberculosis patients was 91.89%(2617/2848).The drug sensitivity test of tuberculosis showed that the overall drug resistance rate was 22.55%(53/235),the multi-drug resistance rate was 10.64%,and the multiple drug resistance rate was 6.38%.Conclusion The annual reported incidence rate of tuberculosis in Wuyuan county showed a decreasing trend year by year,but the proportion of drug-resistant tuberculosis patients was relatively high.In future,we should pay more attention to key groups such as men and elderly residents,focus on health education,monitoring and intervention,strictly implement standardized treatment for tuberculosis patients,and reduce the incidence rate of tuberculosis,and anti-tuberculosis drug resistance rate.
作者
程媛
吴欣欣
CHENG Yuan;WU Xinxin(Wuyuan County Center for Disease Control and Prevention,Wuyuan 333200,Jiangxi Province,China)
出处
《世界临床药物》
CAS
2023年第3期275-280,共6页
World Clinical Drug
关键词
结核病
报告发病率
耐药结核菌
重点人群
多耐药结核病
tuberculosis
reported incidence rate
drug resistant tuberculosis bacteria
key population
multi-drug resistant tuberculosis
