摘要
目的:探讨右美托咪定联合地塞米松对结直肠癌患者苏醒质量、应激反应和外周血T细胞亚群的影响。方法:选择2020年4月~2021年3月期间我院收治的结直肠癌患者132例,采用随机数字表法分为对照组(右美托咪定,n=66)和研究组(右美托咪定联合地塞米松,n=66)。观察两组血流动力学、苏醒质量、应激反应、T细胞亚群和不良反应。结果:研究组给药后10 min(T1)~出手术室时(T4)时间点平均动脉压(MAP)、心率(HR)低于对照组(P<0.05)。研究组T1~T4时间点去甲肾上腺素(NE)、肾上腺素(E)较对照组低(P<0.05)。两组睁眼时间、术后自主呼吸恢复时间、拔管时间组间对比无差异(P>0.05)。研究组术后3 d CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。两组不良反应发生率组间对比无差异(P>0.05)。结论:右美托咪定联合地塞米松用于结直肠癌患者,可保持良好的苏醒质量,减轻机体应激反应和免疫抑制,改善血流动力学波动。
Objective:To investigate the effects of dexmedetomidine combined with dexamethasone on awakening quality,stress response and peripheral blood T cell subsets in patients with colorectal cancer.Methods:132 patients with colorectal cancer who were received in our hospital from April 2020 toMarch 2021 were selected,and they were divided into control group(dexmedetomidine,n=66)and study group(dexmedetomidine combined with dexamethasone,n=66)by random number table method.Hemodynamics,awakening quality,stress response,T cell subsets and adverse reactions were observed of the two groups.Results:The mean arterial pressure(MAP)and heart rate(HR)of the study group were lower than those of the control group at the time point from 10min(T1)to the time point from the operating room(T4)after administration(P<0.05).The norepinephrine(NE)and epinephrine(E)of the study group were lower than those of the control group at T1~T4(P<0.05).There were no differences in eye opening time,recovery time of spontaneous respiration after operation and extubation time of the two groups(P>0.05).CD3^(+),CD4^(+),CD4^(+)/CD8^(+)of the study group at 3 d after operation were higher than those of the control group,and CD8^(+)was lower than that of the control group(P<0.05).There was no difference in the incidence of adverse reactions of the two groups(P>0.05).Conclusion:Dexmedetomidine combined with dexamethasone in patients with colorectal cancer can maintain good awakening quality,reduce body's stress response and immune suppression,and improve hemodynamic fluctuations.
作者
柴青
周海娇
王朝集
段红
舒进军
张宏伟
CHAI Qing;ZHOU Hai-jiao;WANG Chao-ji;DUAN Hong;SHU Jin-jun;ZHANG Hong-wei(Department of Anesthesiology,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center/Cancer Hospital Affiliate to School Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan,610041,China;Department of Anesthesiology,Gansu Provincial Hospital,Lanzhou,Gansu,730013,China)
出处
《现代生物医学进展》
CAS
2023年第8期1493-1496,1535,共5页
Progress in Modern Biomedicine
基金
四川省卫生健康委员会普及应用项目(18PJ162)。
关键词
右美托咪定
地塞米松
结直肠癌
苏醒质量
应激反应
T细胞亚群
Dexmedetomidine
Dexamethasone
Colorectal cancer
Awakening quality
Stress response
T cell subpopulation
