摘要
目的探讨类风湿关节炎(RA)中Boolean缓解与其他缓解的关系。方法回顾性纳入经治疗后评估28个关节疾病活动评分-红细胞沉降率(DAS28-ESR)<2.6的RA患者154例(总体组),根据病情缓解持续时间将其分为缓解≥6个月组99例和缓解<6个月组55例。比较3组患者在不同缓解标准下的RA缓解率及在不同患者总体评估(PGA)下Boolean缓解标准与简化疾病活动指数(SDAI)缓解标准的一致性。结果3组患者在Boolean缓解标准下的RA缓解率均低于同组SDAI、临床疾病活动指数(CDAI)缓解标准下的RA缓解率(P<0.05),而3组患者Boolean缓解标准和超声影像学缓解标准下的RA缓解率比较差异均无统计学意义(P>0.05)。当PGA=2.0 cm时,总体组、缓解≥6个月组及缓解<6个月组患者Boolean缓解标准与SDAI缓解标准的一致性均最高(kappa值依次为0.922、0.809、0.867)。结论在RA患者中,Boolean缓解标准较SDAI、CDAI、DAS28-ESR缓解标准更严格,但与超声影像学缓解标准比较无显著差异,PGA=2.0 cm时的Boolean缓解标准与SDAI缓解标准具有高度一致性。
Objective To explore the relationship between Boolean remission and other remission in rheumatoid arthritis(RA).Methods A total of 154 RA patients with twenty-eight joint disease activity scores-erythrocyte sedimentation rate(DAS28-ESR)<2.6 after treatment(total group)were retrospectively selected and divided into remission≥6 months group(99 cases)and remission<6 months group(55 cases)according to duration of remission.RA remission rate under different remission criteria and the consistency of Boolean remission criteria with Simplified Disease Activity Index(SDAI)under different patient global assessment(PGA)were compared among 3 groups.Results RA remission rate under Boolean remission criteria was lower than those under SDAI and clinical disease activity index(CDAI)remission criteria in total group,remission≥6 months group and remission<6 months group(P<0.05),while there was no significant difference of RA remission rate under Boolean remission criteria and ultrasound imaging remission criteria among 3 groups(P>0.05).When PGA=2.0 cm,Boolean remission criteria had the highest consistency with SDAI remission criteria in total group,remission≥6 months group and remission<6 months group(kappa value were 0.922,0.809,0.867 in turn).Conclusion In RA patients,Boolean remission criteria is more stringent than SDAI,CDAI and DAS28-ESR remission criteria,but there is no significant difference compared with ultrasound imaging remission criteria.Boolean remission criteria has the highest consistency with SDAI remission criteria when PGA=2.0 cm.
作者
刘宏艳
包金环
魏华
Liu Hongyan;Bao Jinhuan;Wei Hua(Department of Rheumatology and Immunology,Taixing People's Hospital,Taixing 225400,China;不详)
出处
《临床内科杂志》
CAS
2023年第3期171-174,共4页
Journal of Clinical Internal Medicine
关键词
类风湿关节炎
患者总体评估
缓解标准
一致性
Rheumatoid arthritis
Patient global assessment
Remission criteria
Consistency
