摘要
先兆流产合并宫腔积血是妊娠期常见疾病,其发病机制与母胎界面微环境失衡、子宫螺旋动脉重塑受阻有关。滋养层细胞是母胎界面微环境的最外层,其增殖、迁移及侵袭与正常妊娠密切相关,在免疫耐受与调节、子宫螺旋动脉重塑、维持母胎界面微环境等方面发挥着不可替代的作用。近年来滋养层细胞已经成为自身免疫性疾病等领域的研究主线,研究发现其在先兆流产合并宫腔积血的诊治中发挥重要作用。本文就滋养层细胞在先兆流产合并宫腔积血中的研究进展进行综述。
Threatened abortion complicated with intrauterine hemorrhage is a common disease during pregnancy.Its pathogenesis is related to an imbalance of the maternal⁃fetal interface microenvironment and obstruction of uterine spiral artery remodeling.Trophoblast cells compose the outermost layer of the maternal⁃fetal interface microenvironment.Their proliferation,migration,and invasion are closely related to normal pregnancy.They play an irreplaceable role in immune tolerance and regulation,uterine spiral artery remodeling,and maintenance of the maternal⁃fetal interface microenvironment.In recent years,trophoblast cells have become the main research focus in autoimmune diseases and other fields.Studies have shown that trophoblast cells play an important role in the diagnosis and treatment of threatened abortion complicated with intrauterine hemorrhage.This article reviews the research progress of trophoblast cells in the treatment of threatened abortion complicated with intrauterine hemorrhage.
作者
霍艳
陈萍
朱俊楠
付雅琪
徐广立
HUO Yan;CHEN Ping;ZHU Junnan;FU Yaqi;XU Guangli(the First Clinical Medical of Henan University of Chinese Medicine,Zhengzhou 450000,China;the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450099)
出处
《中国比较医学杂志》
CAS
北大核心
2023年第5期127-133,共7页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金项目(82074167)
河南省自然科学基金项目(202300410265)。
关键词
先兆流产
宫腔积血
滋养层细胞
母胎界面
螺旋动脉重塑
threatened abortion
intrauterine hematomas
trophoblast cell
maternal⁃fetal interface
remodeling uterine spiral arteries
