摘要
支架引导再生在创伤、肿瘤、切除等引起的严重骨缺损的治疗和修复中起着至关重要的作用。目前发展的磁性功能支架已被证明自身或者结合外部磁场可以影响细胞代谢行为,通过磁性环境来促进骨组织再生。特别是其结合外部磁场的作用,可以有效远程控制药物释放和激活细胞表面通道,介导一系列成骨相关通路,诱导细胞分化,促进组织生长、骨缺损再生等反应。同样,磁性支架在热疗、磁共振成像、靶向递送等方面也有着广泛的应用潜能。磁性支架可提高骨组织工程效率,为骨缺损的修复提供了一定保障。本文综述了磁性支架的复合、制备技术、促进骨再生的机制,以及磁场和磁性支架的协同功能,并总结了几种磁性功能支架在骨组织修复工程领域中的研究及应用。
Scaffold-guided regeneration performs an essential function in the therapy of severe bone defects caused by trauma,tumor,resection,etc.Magnetic scaffolds have been demonstrated to influence cellular metabolic behavior by themselves or external magnetic fields.In particular,the synergistic function of magnetic scaffolds and external magnetic fields can effectively control the release of drugs and activate channels on the cell surface to mediate a series of osteogenesis-related pathways,promoting cell differentiation and tissue regeneration.Additionally,the magne-tic scaffolds have potential applications in thermal therapy,magnetic resonance imaging,targeted delivery,etc.The magnetic scaffolds provide a certain guarantee for improving the repair efficiency of bone tissue engineering.The composite methods,preparation technologies and mechanism of promoting bone regeneration for the magnetic scaffolds,as well as the synergistic function of magnetic field and magnetic scaffold,are reviewed in this paper.It also summarizes the applicatory research of several magnetic scaffolds in bone tissue repair engineering.
作者
段晶
吴佳蕾
林涛
邵慧萍
DUAN Jing;WU Jialei;LIN Tao;SHAO Huiping(Institute of Advanced Materials and Technology,University of Science and Technology Beijing,Beijing 100083,China)
出处
《材料导报》
EI
CAS
CSCD
北大核心
2023年第10期194-202,共9页
Materials Reports
