摘要
目的研究红细胞分布宽度(RDW)、血小板/淋巴细胞比值(PLR)、中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞/单核细胞比值(LMR)、系统免疫炎症指数(SII)对HBV相关肝脏疾病进展的预测价值。方法选择2018年1月至2020年12月在运城市中心医院首次就诊的470例HBV相关肝病住院患者,将其分为CHB组(n=119)、肝硬化代偿期组(n=116)、肝硬化失代偿期组(n=117)、HCC组(n=118)。比较4组的年龄、性别构成,以及RDW、PLR、NLR、LMR、SII的差异;分析影响HBV相关肝病进展的因素;采用ROC曲线分析各项指标对HBV相关肝病进展的预测效能。结果单因素logistic回归分析结果显示,与CHB组相比,年龄增加会使肝硬化代偿期、肝硬化失代偿期、HCC的发生风险均增高(P均<0.05);NLR和RDW升高会使肝硬化失代偿期和HCC的发生风险均增高(P均<0.05);PLR和SII升高均会使肝硬化代偿期的发生风险降低(P均<0.05),HCC的发生风险增高(P均<0.05)。多因素logistic回归分析结果显示,与CHB组相比,年龄增加和NLR升高均会使肝硬化代偿期、肝硬化失代偿期、HCC的发生风险增高(P均<0.05)。将肝硬化失代偿期组、HCC组设为疾病进展组,将CHB组、肝硬化代偿期设为对照组,ROC曲线分析结果显示,与RDW、LMR、PLR、SII相比,NLR预测HBV相关肝病进展的效能较好(P<0.05)。结论在外周血细胞指标中,与RDW、LMR、PLR、SII相比,NLR对HBV相关肝病进展的预测价值较高。
Objective This paper aimed to observe the predictive value of red blood cell distribution width(RDW),platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR),and systemic immune inflammation index(SII)in the progression of HBV related liver disease.Methods Four hundred and seventy hospitalized patients with HBV related liver diseases who were diagnosed for the first time at Yuncheng Central Hospital from January 2018 to December 2020 were selected and assigned to the CHB group(n=119),the compensated liver cirrhosis group(n=116),the decompensated liver cirrhosis group(n=117),and the HCC group(n=118).The age,gender composition,and differences in RDW,PLR,NLR,LMR,and SII were compared among the four groups.The factors affecting the progression of HBV related liver diseases were analyzed.The predictive efficacy of various indicators on the progression of HBV related liver disease was analyzed using ROC curves.Results The results of univariate logistic regression analysis show that compared with the CHB group,increasing age can increase the risk of compensatory phase in liver cirrhosis,decompensated phase in liver cirrhosis,and HCC(P<0.05).Elevated NLR and RDW can increase the risk of decompensation in liver cirrhosis and HCC(P<0.05).Elevated PLR and SII can reduce the risk of compensatory phase in liver cirrhosis(P<0.05)and increase the risk of HCC(P<0.05).The results of multivariate logistic regression analysis show that compared with the CHB group,increasing age and NLR both increase the risk of compensatory phase in liver cirrhosis,decompensated phase in liver cirrhosis,and HCC(P<0.05).The decompensated liver cirrhosis group and HCC group are set as disease progression groups,while the CHB group and compensated liver cirrhosis group are set as control groups.The ROC curve analysis results show that compared with RDW,LMR,PLR,and SII,NLR has a better predictive effect on HBV related liver disease progression(P<0.05).Conclusion Compared with RDW,LMR,PLR,and SII in periphe
作者
常柳祎
秦丽静
王卫民
CHANG Liuyi;QIN Lijing;WANG Weimin(Department of Gastroenterology,Yuncheng Central Hospital,Yuncheng 044000,China)
出处
《国际消化病杂志》
CAS
2023年第2期97-102,共6页
International Journal of Digestive Diseases
基金
山西省运城市中心医院院级课题(YJ2022044)。
