摘要
目的观察中心性浆液性脉络膜视网膜病变(CSC)患眼黄斑下液(SMF)与脉络膜血流状态的关系。方法去回顾性研究。2021年8月1日至2023年3月1日于北京大学人民医院眼科中心检查确诊的CSC患者29例31只眼纳入研究。根据末次随访时SMF是否完全吸收,将患眼分为完全吸收组、非完全吸收组,分别为14、17只眼。采用图湃(北京)医疗科技有限公司BM400KBMizar行黄斑区扫频源光相干断层扫描血管成像检查。扫描速率1536A扫描×1280B扫描,扫描范围24mm×20mm。设备自带软件记录上、上方、鼻上、题侧、中心凹区、鼻侧、下、下方、鼻下共9个分区的脉络膜厚度(CT)、脉络膜毛细血管层血流密度、脉络膜中大血管层血流密度、三维脉络膜血管指数(CVI)、单位面积(每1mm^(2))平均脉络膜血管体积(mCVV)、单位面积(每1mm^(2))平均脉络膜基质体积(mCSV)。对于完全吸收组、非完全吸收组之间的比较,连续变量采用独立样本t检验或Mann-Whitney检验,分类变量采用χ^(2)检验或Fisher检验。多因素logistic回归分析影响SMF完全吸收的相关因素。结果基线时,非完全吸收组患眼上区域CT(Z=2.859,P=0.004)、mCVV(t=2.514,P=0.018)、mCSV(Z=2.958,P=0.003)显著高于完全吸收组,差异均有统计学意义。与基线时比较,末次随访时,完全吸收组涡静脉不对称百分比显著下降(χ^(2)=6.000,P=0.014),题上、鼻上、题侧、中心凹、鼻侧、下、鼻下区域CVI(t=-4.125、t=-3.247、Z=-3.213、t=-2.994、t=-3.417、t=-3.733、t=-3.795,P=0.001、0.006、0.001、0.010、0.005、0.003、0.002)、9个分区mCVV(t=-2.959、t=-2.537、t=-2.235、t=-3.260、t=-3.022、t=-2.796、t=-2.747、Z=-2.107、t=-2.935,P=0.011、0.025、0.044、0.006、0.010、0.015、0.017、0.035、0.012)均显著降低,差异均有统计学意义。相比于完全吸收组,非完全吸收组脉络膜血流变化区域较局限,末次随访时上方区域CT反而显著升高(t=2.272,P=0.037),差异�
Objective To analyze the associations between the choroidal vasculature and submacular fluid(SMF)in central serous chorioretinopathy(CSC).Methods A retrospective study.A total of 29 CSC patients(31 eyes)with complete records who visited the Department of Ophthalmology in Peking University People's Hospital from August 1,2021 to March 1,2023 were included in this study.The patients were divided into complete absorption and incomplete absorption groups according to the status of SMF in the last visit.All the patients underwent ultra-widefield swept-source optical coherence tomography angiography(UWF SSOCTA)with a scanning range of 24 mm × 20 mm.The UWF SS-OCTA images were automatically analyzed in 9 regions(superotemporal,superior,superonasal,temporal,central,nasal,inferotemporal,inferior,and inferonasal).Alterations of choroidal vasculature in the nine subfields after SMF absorption were described,including choroidal thickness(CT),flow density of choriocapillaris layer,vessel density of large choroidal vessel layer,three-dimensional choroidal vascularity index(CVI),the mean choroidal vessel volume(mCVV),and the mean choroidal stroma volume(mCSV).The relevant factors affecting the complete absorption of SMF were additionally evaluated.Results At baseline,CT(Z=2.859,P=0.004),mCVV(t-2.514,P=0.018),and mCSV(Z=2.958,P=0.003)in the superotemporal region of the affected eyes in the incomplete absorption group were significantly higher than those in the complete absorption group.Compared with baseline,at the last visit,the proportion of asymmetric vortex veins in the complete absorption group was significantly decreased(χ^(2)=6.000,P=0.014),CVI in the superotemporal,superonasal,temporal,central,nasal,inferotemporal,and inferonasal regions(t=-4.125,t=-3.247,Z=-3.213,t=-2.994,t=-3.417,t=-3.733,t=-3.795;P=0.001,0.006,0.001,0.010,0.005,0.003,0.002),the mCVV of 9 regions(t=-2.959,t=-2.537,t=-2.235,t=-3.260,t=-3.022,t=-2.796,t=-2.747,Z=-2.107,t=2.935;P=0.011,0.025,0.044,0.006,0.010,0.015,0.017,0.035,0.012)were significantly d
作者
曾巧珠
姚昱欧
涂书
赵明威
Zeng Qiaozhu;Yao Yuou;Tu Shu;Zhao Mingwei(Department of Ophthalmology,Peking University People's Hospital,Eye Diseases and Optometry Institute,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases,College of Optometry,Peking University Health Science Center,Beijing 100044,China)
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2023年第4期297-306,共10页
Chinese Journal of Ocular Fundus Diseases
基金
国家重点研发计划(2020YFC2008200)。
