摘要
目的 了解内脏脂肪与胰腺癌关系相关研究的进展。方法 对近年来国内外在内脏脂肪的蓄积、内脏脂肪与胰腺癌关系的潜在机制、内脏脂肪的测量以及内脏脂肪与胰腺癌预后方面相关研究的文献予以综述。结果 内脏脂肪的蓄积是多因素共同作用的结果,包括年龄、性别及性激素、内源性大麻素系统等,它分泌的多种脂肪因子在胰腺癌的发生及发展中起到了至关重要的作用,主要通过多种不同信号通路发挥促肿瘤和抗肿瘤效应。结论 临床治疗过程中,可在不影响患者病情进展的条件下,通过调整饮食、体育训练等方法降低内脏脂肪量,同时干预各种脂肪因子的作用路径,以此来改善胰腺癌患者的生活质量及生存预后。
Objective To summarize the research progress of relation between visceral fat and pancreatic cancer.Method The domestic and foreign literature on the accumulation of visceral fat,the potential mechanism of association between visceral fat and pancreatic cancer,the measurement of visceral fat,and the association of visceral fat with prognosis for pancreatic cancer in recent years was reviewed.Results The accumulation of visceral fat was the result of multiple factors,including age,gender,sex hormones,endocannabinoid system,etc.A variety of adipokines secreted by visceral fat played a crucial role in the occurrence and development of pancreatic cancer,which played a pro-tumor and anti-tumor effects mainly through a variety of different signal pathways.Conclusions In clinical treatment,the quality of life and prognosis of patients with pancreatic cancer can be improved by reducing visceral fat mass by adjusting diet,physical training,and other methods,as well as intervening the action signal pathways of various adipokines without affectingthediseaseprogression.
作者
马小鹏
杜昊轩
朱克祥
MA Xiaopeng;DU Haoxuan;ZHU Kexiang(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,P.R.China;Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou 730000,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2023年第4期484-489,共6页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金(项目编号:81960516)。
关键词
内脏脂肪
胰腺癌
预后
综述
visceral fat
pancreatic cancer
prognosis
review
