摘要
骨关节炎(OA)临床通常被称为“磨损性”关节炎,是最常见的流行性退行性关节炎,是导致残疾的主要原因,目前对其潜在分子机制尚未完全了解。microRNA已被证明在不同疾病中调节不同的细胞过程,包括软骨细胞和骨细胞的代谢活动。核因子κB(NF-κB)转录因子是OA常见的一种疾病促发因子。越来越多的研究表明,靶向NF-κB通路可以为OA损伤提供新的潜在治疗选择,并降低潜在副作用的风险。本文系统阐述了microRNA与NF-κB通路在OA发病机制中的作用,包括两者单体和联合对OA作用机制以及基于两者在OA临床治疗的调节机制,以期将更加有助于阐明OA的发病机制,探索新的诊断生物标志物和潜在治疗靶点。
Osteoarthritis(OA),often referred to as"wear and tear"arthritis,is the most common epidemic degenerative arthritis and the main cause of disability.Currently,the underlying molecular mechanism is not fully understood.Micrornas have been shown to regulate different cellular processes in different diseases,including the metabolic activity of chondrocytes and bone cells.Nuclear factorκB(NF-κB)transcription factor is a common disease promoter of OA.A growing number of studies suggest that targeting the NF-κB pathway could provide new potential therapeutic options for OA injury and reduce the risk of potential side effects.This paper systematically elaborated the roles of microRNA and NF-KB pathways in the pathogenesis of OA,including the mechanism of action of both rorNA and NF-KB pathways on OA and the regulatory mechanism based on the clinical treatment of OA,in order to better clarify the pathogenesis of OA and explore new diagnostic biomarkers and potential therapeutic targets.
作者
潘盛强(综述)
谢兴文(审校)
李宁(审校)
PAN Shengqiang;XIE Xingwen;LI Ning(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《西部医学》
2023年第5期775-780,共6页
Medical Journal of West China
基金
国家自然科学基金项目(82060873)。
