摘要
提高生物医学研究结果的可重复性是一项重大挑战,研究人员透明且准确地报告其研究过程有利于读者对该研究结果的可靠性进行评估,进而重复该实验或在该成果的基础上进一步探索。ARRIVE 2.0指南是2019年英国国家3Rs中心(NC3Rs)组织发布的一份适用于任何与活体动物研究报告相关的指导性清单,用以提高动物体内实验设计、实验实施和实验报告的规范性,以及动物实验结果的可靠性、可重复性和临床转化率。ARRIVE 2.0指南的使用不仅可以丰富动物实验研究报告的细节,确保动物实验结果信息被充分评估和利用,还可以使读者准确且清晰地了解作者所表述的内容,促进基础研究评审过程的透明化和完整性。目前,ARRIVE 2.0指南已经被国际生物医学期刊广泛采纳。本文是在国际期刊遵循ARRIVE 2.0指南的最佳实践基础上,对2020年发表于PLoS Biology期刊上的ARRIVE 2.0指南完整解读版(原文请见https://arriveguidelines.org)进行中文编译(第一部分包括前言和“关键10条”里的“研究设计”“样本量”“纳入和排除标准”),以期促进国内研究人员充分理解并使用ARRIVE 2.0指南,提高实验动物研究及报告的规范性,助推我国实验动物科技与比较医学研究的高质量发展。
Improving the reproducibility of biomedical research results is a major challenge.Researchers reporting their research process transparently and accurately can help readers evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings.The ARRIVE 2.0 guidelines,released in 2019 by the UK National Centre for the Replacement,Refinement and Reduction of Animals in Research(NC3Rs),provide a checklist applicable to any in vivo animal research report.These guidelines aim to improve the standardization of experimental design,implementation,and reporting,as well as the reliability,repeatability,and clinical translatability of animal experimental results.The use of ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports,ensuring that information on animal experimental results is fully evaluated and utilized,but also enables readers to understand the content expressed by the author accurately and clearly,promoting the transparency and integrity of the fundamental research review process.At present,the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals.this article is a Chinese translation based on the best practices of international journals following the ARRIVE 2.0 guidelines in international journals,specifically for the complete interpretation of the ARRIVE 2.0 guidelines published in the PLoS Biology journal in 2020(original text can be found at https://arriveguidelines.org).The first part of the article includes the preface and the"Key 10"section,which covers"study design""sample size"and"inclusion and exclusion criteria".Its aim is to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers,enhance the standardization of experimental animal research and reporting,and promote the high-quality development of experimental animal technology and comparative medicine research in China.
作者
王剑
卢今
马政文
陈国元
卢晓
白玉
刘晓宇
卢选成
高静
李垚
庞万勇
WANG Jian;LU Jin;MA Zhengwen;CHEN Guoyuan;LU Xiao;BAI Yu;LIU Xiaoyu;LU Xuancheng;GAO Jing;LI Yao;Pang Wanyong(Department of Laboratory Animal Science,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China;Animal Core Facility,Center for Excellence in Molecular Cell Science,Chinese Academy of Science,Shanghai 200031,China;Dizal Pharmaceuticals Co.,Ltd.,Shanghai 201203,China;Novo Nordisk Research Centre China,Beijing 102206,China;National Institute for Occupational Health and Poison Control,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Laboratory Animal Center,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Clinical Research Institute,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Translational in Vivo Model Research Platform,Sanofi G&D,Beijing 100022,China)
出处
《实验动物与比较医学》
CAS
2023年第2期213-224,共12页
Laboratory Animal and Comparative Medicine
