摘要
目的 探究喹硫平与奥氮平治疗老年器质性精神障碍的疗效。方法 104例老年器质性精神障碍患者,随机分为实验组与对照组,各52例。对照组使用奥氮平治疗,实验组使用喹硫平治疗。比较两组治疗前后的简明精神病评定量表(BPRS)评分及焦虑、抑郁自评量表评分,临床疗效,治疗显效时间。结果 两组治疗前及治疗后1、2、4、8周的BPRS评分比较,差异无统计学意义(P>0.05)。实验组治疗总有效率98.08%与对照组的94.23%比较,差异无统计学意义(P>0.05)。治疗后,实验组的焦虑自评量表评分、抑郁自评量表评分分别为(31.57±3.22)、(32.20±2.36)分,均低于对照组的(46.67±4.90)、(45.16±2.78)分,差异有统计学意义(P<0.05)。实验组治疗显效时间(6.22±1.26)d短于对照组的(8.68±1.79)d,差异有统计学意义(P<0.05)。结论 老年器质性精神障碍患者应用喹硫平治疗可改善患者抑郁、焦虑状态,缩短治疗时间,值得进一步推广。
Objective To investigate the efficacy of quetiapine and olanzapine in the treatment of organic mental disorders in the elderly.Methods A total of 104 elderly patients with organic mental disorders were randomly divided into experimental group and control group,with 52 cases in each group.The control group was treated with olanzapine,and the experimental group with quetiapine.Both groups were compared in terms of brief psychiatric ratmg scale(BPRS)score,self-rating anxiety scale score and self-rating depression scale score before and after treatment,clinical efficacy and onset time of treatment.Results There was no statistically significant difference in BPRS scores between the two groups before treatment and at 1,2,4 and 8 weeks after treatment(P>0.05).The total effective rate of the experimental group was 98.08%,and the difference was not statistically significant when compared with 94.23%of the control group(P>0.05).After treatment,the selfrating anxiety scale score and self-rating depression scale score in the experimental group were(31.57±3.22)and(32.20±2.36)points,which were lower than those of(46.67±4.90)and(45.16±2.78)points in the control group,and the differences were statistically significant(P<0.05).The onset time of treatment in the experimental group was(6.22±1.26)d,which was shorter than that of(8.68±1.79)d in the control group,and the difference was statistically significant(P<0.05).Conclusion Quetiapine can improve the depression and anxiety state of the elderly patients with organic mental disorders and shorten the treatment time.It is worthy of further promotion.
作者
路鹏
LU Peng(Anshan Mental Health Center,Anshan 114000,China)
出处
《中国现代药物应用》
2023年第8期115-117,共3页
Chinese Journal of Modern Drug Application
关键词
喹硫平
奥氮平
器质性精神障碍
疗效
Quetiapine
Olanzapine
Organic mental disorders
Efficacy
