摘要
目的:观察自拟解毒降糖复瘫汤治疗糖尿病并发急性脑梗死患者的临床疗效,并探讨其对患者血清炎性因子水平(IL-10、TNF-α、hs-CRP)的影响。方法:收集120例糖尿病并发急性脑梗死患者,随机分为观察组和对照组,各60例。2组在基础治疗上,观察组予以自拟解毒降糖复瘫汤治疗,对照组予以传统补阳还五汤治疗,评估2组治疗前后脑卒中残损评定法评分(SIAS)、Barthel指数评分(BI)、简明精神状态检查表评分(MMSE)以及炎性因子水平(IL-10、TNF-α、hs-CRP),并比较疗效差异。结果:治疗1疗程后,2组糖尿病并发急性脑梗死患者的SIAS、BI、MMSE、炎性因子水平(IL-10、TNF-α、hs-CRP)和总体疗效均有改善,其中在治疗后总体疗效、功能评分、TNF-α和hs-CRP水平方面2组间比较具有显著性差异(P<0.05),而治疗后2组IL-10水平比较无显著性差异(P>0.05)。结论:自拟解毒降糖复瘫汤治疗糖尿病并发急性脑梗死患者疗效明显,能提高患者治疗有效率,改善患者神经功能和日常生活能力,调节患者血清炎性因子水平,值得临床推广应用。
Objective:To evaluate the clinical effect of self-made Jiedu Jiangtang Futan Formula on patients with diabetes and acute cerebral infarction,and to explore the prescription to the patients with serum inflammatory factors level(IL-10,TNF-αand hs-CRP).Methods:120 patients with diabetic and acute cerebral infarction were randomLy divided into observation group and control group,with 60 cases in each group.On the foundation treatment in both groups,the patients in the control group were given Buyang Huanwu Decoction and the patients in the observation group were given self-made Jiedu Jiangtang Futan Formula.The two groups were evaluated by stroke impairment assessment set(SIAS),Barthl index(BI),min-imental state examination(MMSE),inflammatory factor levels(IL-10,TNF-αand hs-CRP),and compared the difference of curative effect.Results:After one course of treatment,the SIAS,BI,MMSE scores,inflammatory factor levels(IL-10,TNF-αand hs-CRP)and overall efficacy of patients in the acute phase of diabetic cerebral infarction in both groups were improved,and the efficacy,functional scores,TNF-αand hs-CRP level after treatment of patients in the observation group were significantly better than those in the control group(P<0.05),and IL-10 level after treatment has no obvious difference between the two groups(P>0.05).Conclusion:Self-made Jiedu Jiangtang Futan Formula treatment for the patients with diabetic cerebral infarction in acute can improve the clinically curative effect,improve nerve function defect and disability degree,adjust the level of serum inflammatory factors,and is worth clinical promotion.
作者
彭天忠
万青
谢桂
周成
熊佳
廖小香
胡穗发
PENG Tian-zhong;WAN Qing;XIE Gui;ZHOU Cheng;XIONG Jia;LIAO Xiao-xiang;HU Sui-fa(Department of Neurology,Nanchang Hongdu Hospital of Traditional Chinese Medicine,Nanchang 330008,China)
出处
《江西中医药大学学报》
2023年第2期33-36,共4页
Journal of Jiangxi University of Chinese Medicine
基金
江西省卫健委科技计划项目(20187062)。
关键词
自拟解毒降糖复瘫汤
糖尿病
急性脑梗死
血清炎性因子
临床疗效
Self-made Jiedu Jiangtang Futan Formula
Diabetes
Acute Cerebral Infarction
Serum Inflammatory Factors
Clinical Curative Effect
