摘要
目的观察甘油三酯葡萄糖指数(triglyceride-glucose index,TyG)、体质量指数(body mass index,BMI)和复合指标TyG-BMI与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)发病的相关性,比较3个指标对NAFLD的预测价值。方法选取2021年1月~2022年2月于长沙市第四医院诊断为NAFLD患者131例(NAFLD组)及同期来院接受健康体检且身体健康,B超等未检测出脂肪肝的250名成年人作为研究对象(健康对照组)。比较NAFLD组与健康对照组的肝功能、血脂、空腹血糖、TyG指数、TyG-BMI等指标。TyG指数、BMI、TyG-BMI按照四分位数分为4组(Q1~Q4),观察各组NAFLD患病率。使用受试者工作特征曲线评价3个指标对NAFLD的诊断价值。结果NAFLD组TC、TG、LDL-C、ALT、FPG、BMI、TyG指数、TyG-BMI高于健康对照组,HDL-C低于健康对照组,差异有统计学意义(P<0.05)。随着TyG指数、BMI、TyG-BMI的升高,NAFLD患病率亦升高。3个指标Q4、Q3四分位组的NAFLD患病率均高于Q1四分位组,Q4四分位组患病率均高于Q2四分位组;TyG指数和TyG-BMI的Q4四分位组患病率高于Q3四分位组;BMI和TyG-BMI的Q2四分位组患病率高于Q1四分位组;TyG-BMI Q3四分位组的NAFLD患病率高于Q2四分位组,差异均有统计学意义(P<0.05)。TyG指数、BMI、TyG-BMI的ROC曲线下面积分别为0.732、0.698、0.796,TyG-BMI对NAFLD的预测价值高于TyG指数和BMI。结论TyG指数、BMI、TyG-BMI升高均与NAFLD发生风险升高相关,与TyG指数、BMI相比,TyG-BMI对NAFLD的预测价值更高。
Objective To observe the correlation between triglyceride glucose index(TyG),body mass index(BMI)and composite index TyG-BMI and the incidence of nonalcoholic fatty liver disease(NAFLD),and to compare the predictive value of three indicators for NAFLD.Methods From January 2021 to February 2022,131 patients with NAFLD and 250 in good health adults who came to the hospital for physical examination at the same time,and no fatty liver was detected by ultra-sound radiography,were taken as the study subjects.The liver function,blood lipid,fasting blood glucose,TyG index,TyG-BMI and other indicators of NAFLD group and normal control group were compared.The TyG index,BMI and TyG-BMI were divided into four groups according to the quartile(Q1~Q4),and the incidence of NAFLD in each group was observed.The diagnostic value of the three indicators for NAFLD were evaluated using the subject work characteristic curve.Results In NAFLD group,TC,TG,LDL-C,ALT,FPG,BMI,TyG index and TyG-BMI were higher than those in the normal control group,while HDL-C was lower than those in the normal control group,with statistical significance(P<0.05).With the increase of TyG index,BMI,and TyG-BMI,the incidence rate of NAFLD also increased.The incidence rate of NAFLD in the Q4 and Q3 quartiles of the three indicators were higher than that in the Q1 quartile,and the incidence rate in the Q4 quartile was higher than that in the Q2 quartile;The incidence rate of the Q4 quartile of TyG index and TyG-BMI were higher than that of the Q3 quartile;The incidence rate of BMI and TyG-BMI in Q2 quartile were higher than that in Q1 quartile;The incidence rate of NAFLD in the Q3 quartile of TyG-BMI was higher than that in the Q2 quartile;The difference was statistically significant(P<0.05).The area under the ROC curve of TyG index,BMI and TyG-BMI is 0.732,0.698 and 0.796 respectively.The predictive value of TyG-BMI on NAFLD is higher than that of TyG index and BMI.Conclusion The rise of TyG index,BMI,and TyG-BMI is related to the increased risk of NAFLD.Compared
作者
张沥
陈海滨
宋俊华
Zhang Li;Cheng Haibin;Song Junhua(Department of Endocrinology,the Fourteh Hospital of Changsha,Changsha 410006,China)
出处
《中华保健医学杂志》
2023年第2期151-154,共4页
Chinese Journal of Health Care and Medicine
基金
湖南省卫健委科技计划项目(202203063065)。
