摘要
目的 系统评价非酒精性脂肪性肝病(NAFLD)的存在及病理改变与血清铁蛋白和血清铁含量变化的关系。方法 检索PubMed、中国知网、维普、万方、Cochrane图书馆等数据库,收集从建库至2021年12月发表的NAFLD的存在及病理改变与血清铁蛋白和血清铁含量变化的关系的中英文文献。对文献进行二次筛选、质量评价及数据提取,采用Stata 12.0软件进行meta分析。结果 共纳入32篇文献,合计4 177例患者。Meta分析结果显示:与对照组相比,NAFLD患者血清铁蛋白(SMD=0.93,95%CI:0.85~1.01,P=0.000)和血清铁(SMD=0.57,95%CI:0.37~0.76,P=0.000)含量较高;与单纯性脂肪肝患者相比,非酒精性脂肪性肝炎患者血清铁蛋白(SMD=0.59,95%CI:0.41~0.78,P=0.000)含量较高,而血清铁(SMD=0.14,95%CI:0.00~0.29,P=0.057)含量两者差异无统计学意义。结论 NAFLD的存在与血清铁蛋白和血清铁含量增多具有相关性,并且NAFLD病理改变越严重,血清铁蛋白和血清铁含量越高。因此,血清铁蛋白和血清铁在NAFLD进展中的因果作用及NAFLD的发病机制值得进一步研究及临床验证。
Objective To systematically evaluate the correlation between pathological changes and serum ferritin and iron levels in nonalcoholic fatty liver disease(NAFLD).Methods Chinese and English literatures form PubMed,China National Knowledge Internet(CNKI),VIP,Wanfang Data,Cochrane Library,published up to December 2021,regarding the correlation between pathological changes and serum ferritin and iron levels in NAFLD,were enrolled.Secondary screening,quality assessment and data extraction were performed,and then Stata12.0 software was used for meta-analysis.Results Thirty-two articles were included,representing 4177 patients.Meta-analysis showed that the serum ferritin(SMD=0.93,95%Cl:0.85-1.01,P=0.000)and serum iron levels(SMD=0.57,95%Cl:0.37-0.76,P=0.000)in NAFLD group were higher than those in the control group.Compared with patients with simple fatty liver,the serum ferritin(SMD=0.59,95%Cl:0.41-0.78,P=0.000)in patients with nonalcoholic steatohepatitis was increased,and but no statistically significant difference in serum iron(SMD=0.14,95%Cl:0.00-0.29,P=0.057).Conclusion The presence of NAFLD correlates with increased serum ferritin and iron levels,and the pathological changes of NAFLD correlates positively with serum ferritin and iron levels.The causal relationship of the threes in NAFLD and the pathogenesis of NAFLD should be further investigation and verification in clinical.
作者
曹宇萌
张海燕
刘立新
Cao Yumeng;Zhang Haiyan;Liu Lixin(Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Shanxi Medical University,Taiyuan 030001,China;Institute of Liver Disease and Organ Transplantation,Shanxi Medical University,Taiyuan 030001,China;First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China)
出处
《临床荟萃》
CAS
2023年第3期197-207,共11页
Clinical Focus
基金
中央引导地方科技发展资金(山西省科技厅)——IGFBPrP1及铁死亡在非酒精性脂肪性肝病中的作用机制研究(YDZX20201400001965)。
