摘要
目的探讨外周血CD3+T细胞趋化因子受体在反复肺炎患儿血清中的表达水平及临床意义。方法选取2019年10月至2021年1月该院98例反复肺炎患儿作为观察组,另选取同期88例急性肺炎患儿为对照1组,80例健康体检儿童为对照2组。比较3组CXCR1、CXCR2及肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV 1)、最大呼气流量(PEF)]水平,分析反复肺炎患儿CXCR1、CXCR2与肺功能相关性,比较1年内再次发作患儿与未发作患儿一般资料及CXCR1、CXCR2水平,分析再次发作的危险因素,以及CXCR1、CXCR2对再次发作的预测价值。结果观察组CXCR1、CXCR2水平较对照1组、对照2组高,对照1组CXCR1、CXCR2水平较对照2组高,观察组、对照1组FVC、FEV 1、PEF较对照2组低(P<0.05),但观察组与对照1组间比较,差异无统计学意义(P>0.05)。CXCR1、CXCR2与FVC、FEV 1、PEF呈负相关(P<0.05)。1年内再次发作患儿营养状况较未发作患儿差(P<0.05),CXCR1、CXCR2水平较未发作患儿高(P<0.05);CXCR1、CXCR2水平高为反复肺炎患儿再次发作的危险因素(P<0.05)。受试者工作特征(ROC)曲线分析显示,CXCR1、CXCR2联合预测再次发作的曲线下面积(AUC)为0.797,高于单独预测(P<0.05)。结论反复肺炎患儿外周血CD3+T细胞趋化因子受体CXCR1、CXCR2水平明显升高,且与肺功能密切相关,通过测定CXCR1、CXCR2水平不仅能评估病情程度,还可对再次发作风险进行评估。
Objective To investigate the expression level and clinical significance of peripheral blood CD3+T cell chemokine receptors in the serum of children with recurrent pneumonia.Methods From October 2019 to January 2021,98 children with recurrent pneumonia in the hospital were selected as the observation group,88 children with acute pneumonia during the same period were selected as the control group 1,and 80 healthy children were selected as the control group 2.The levels of CXCR1,CXCR2 and pulmonary function[forced vital capacity(FVC),forced expiratory volume in the first second(FEV 1)and maximum expiratory flow(PEF)]in the three groups were compared,and the correlation between CXCR1,CXCR2 and pulmonary function in children with recurrent pneumonia was analyzed.The general data and CXCR1 and CXCR2 levels of children with and without recurrence within 1 year were compared,and the risk factors of recurrence were analyzed,as well as the predictive value of CXCR1 and CXCR2 for recurrence.Results The levels of CXCR1 and CXCR2 in the observation group were higher than those in the control group 1 and the control group 2.The levels of CXCR1 and CXCR2 in control group 1 were higher than those in control group 2,while the levels of FVC,FEV 1 and PEF in observation group and control group 1 were lower than those in control group 2(P<0.05).However,there was no statistical significance between observation group and control group 1(P>0.05).CXCR1 and CXCR2 were negatively correlated with FVC,FEV 1 and PEF(P<0.05).The nutritional status of the children with recurrent attacks within 1 year was worse than that of the children without recurrent attacks(P<0.05),and the levels of CXCR1 and CXCR2 were higher than those without recurrent attacks(P<0.05).High CXCR1 and CXCR2 levels were risk factors for recurrent pneumonia in children(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)of CXCR1 and CXCR2 combined in predicting recurrent pneumonia was 0.797,which was higher than that of sing
作者
徐炜新
赵心怡
孙杰
XU Weixin;ZHAO Xinyi;SUN Jie(Department of Clinical Laboratory,Jiading Central Hospital,Shanghai Health Medical College,Shanghai 201800,China)
出处
《国际检验医学杂志》
CAS
2023年第9期1054-1058,共5页
International Journal of Laboratory Medicine
基金
上海市嘉定区自然科学研究课题项目(JDKW-2020-0020)
上海市嘉定区中心医院“双馨培养计划”项目(SX202206)。
