摘要
目的 探究慢性阻塞性肺疾病急性加重(AECOPD)合并支气管扩张患者炎症性指标水平变化及其对病情的诊断价值。方法 回顾性分析阜南县人民医院2018年9月—2021年10月收治的84例AECOPD合并支气管扩张患者的病历资料。收集并整理所有患者入院时的病历资料,于治疗14 d后检测中性粒细胞计数、白细胞计数(WBC)、血清C反应蛋白(CRP)、降钙素原(PCT)、纤维蛋白原(FIB)、总免疫球蛋白E(T-IgE)等炎症相关指标水平,并根据病情进展状况评估结果将其分为进展组和稳定组。分析影响患者病情的相关因素,评估炎症指标对病情的诊断效能。结果 84例AECOPD合并支气管扩张患者中,27例(32.14%)病情稳定;57例(67.86%)患者疾病进展。进展组血清CRP、PCT、FIB及T-IgE表达水平均高于稳定组(P<0.05)。Logistic分析得出,血清CRP、PCT、FIB及T-IgE治疗前后水平变化幅度小,均为AECOPD合并支气管扩张患者病情进展的危险因素(P<0.05)。曲线ROC分析显示,血清CRP差值、PCT差值、FIB差值、T-IgE差值对AECOPD合并支气管扩张患者病情进展诊断的AUC分别为0.804(95%CI:0.700~0.908)、0741(95%CI:0.636~0.846)、0.757(95%CI:0.642~0.873)、0.765(95%CI:0.659~0.870)。结论血清CRP、PCT、FIB、T-IgE表达水平变化与AECOPD合并支气管扩张患者病情变化关系密切,可用于辅助评估病情进展状况。
Objective To explore the changes of inflammatory indexes in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with bronchiectasis and its diagnostic value.Methods The medical records of 84 patients with AECOPD complicated with bronchiectasis treated in the Funan County People's Hospital from September 2018 to October 2021 were analyzed retrospectively.The medical records of all patients at admission were Collected.After 14 days of treatment,the levels of neutrophil count,leukocyte count(WBC),serum Creactive protein(CRP),procalcitonin(PCT),fibrinogen(FIB),total immunoglobulin E(T-IgE)and other inflammation related indicators were detected,and theywere divided into progression group and stable group according to the evaluation results of disease progression.Analyze the relevant factors affecting the patient's condition,and the diagnostic efficacy of inflammatory indicators were evaluated.Results Among 84 cases of AECOPD complicated with bronchiectasis,27 cases(32.14%)were stable;57 patients(67.86%)had disease progression.The expression levels of serum CRP,PCT,FIB and T-IgE in the progressive group were higher than those in the stable group(P<0.05).Logistic analysis showed that the small changes of serum CRP,PCT,FIB and T-IgE before and after treatment were the risk factors for the progression of AECOPD complicated with bronchiectasis(P<0.05).ROC analysis showed that the AUC of serum CRP difference,PCT difference,FIB difference and T-IgE difference in the diagnosis of disease progression in patients with AECOPD complicated with bronchiectasis were 0.804(95%CI:0.700~0.908),0741(95%CI:0.636~0.846),0.757(95%CI:0.642~0.873)and 0.765(95%CI:0.659~0.870),respectively.Conclusion The changes of serum CRP,PCT,FIB and T-IgE expression levels are closely related to the changes of AECOPD patients with bronchiectasis,and can be used to assist in the evaluation of disease progression.
作者
陈刚
王虎
王娇娇
CHEN Gang;WANG Hu;WANG Jiaojiao(Department of Respiratory and Critical Care,Funan County People's Hospital,Fuyang Anhui 236300,China)
出处
《中国急救复苏与灾害医学杂志》
2023年第4期497-500,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
安徽省自然科学基金面上项目(编号:1808085MH228)。
