摘要
骨关节炎又被称之为“骨性关节病”,是由多种因素引起关节软骨纤维化。皲裂、溃疡、脱失而导致以关节疼痛为主要症状的退行性疾病,其发生与年龄、肥胖、炎症、创伤及遗传因素等有关。整合素是一种大的、跨膜的异源二聚体蛋白质,是动物细胞的生长、分化和生存所必需的。为了使细胞能够对动态的细胞外环境做出反应,整合素进化出了一种高度敏感的受体激活机制,主要受三级和四级结构变化的调控。大量研究证实软骨细胞表达整合素α5β1、αVβ3、αVβ5、α6β1、α1β1、α2β1、α10β1和α3β1,其中一些整合素配体可能是OA进展的生物标志物。笔者就整合素及其细胞外配体在骨关节炎研究进展,特别是骨关节炎软骨中的功能作用作一综述。明确整合素及其配体在骨性关节炎软骨中的作用以及为以后进一步治疗关节炎的治疗提供理论基础。
Osteoarthritis,also known as osteoarthropathy,is caused by fibrosis of articular cartilage by a variety of factors.Chaps,ulcers and prolapse lead to degenerative diseases with joint pain as the main symptom.The etiology is not clear,and its occurrence is related to age,obesity,inflammation,trauma and genetic factors.Integrins are large,transmembrane heterodimer proteins that are necessary for the growth,differentiation,and survival of animal cells.In order to enable cells to respond to the dynamic extracellular environment,integrins have evolved a highly sensitive receptor activation mechanism,mainly regulated by tertiary and quaternary structural changes.Many studies have confirmed that chondrocytes express integrinα5β1,αVβ3,αVβ5,α6β1,α1β1,α2β1,α10β1 andα3β1.Some integrin ligands may be biomarkers for the progression of OA.This paper reviews the progress of the research of integrins and their extracellular ligands in osteoarthritis,especially the functional roles of osteoarthritis cartilage.To clarify the role of integrins and ligands in osteoarthritis cartilage and provide theoretical basis for further treatment of arthritis in the future.
作者
江浩
刘俊才
费军
Jiang Hao;Liu Juncai;Fei Jun(Department of orthopaedics,The Affiliated Hospital of Southwest Medical University,Sichuan provincial laboratory of orthopaedic Engineering,Luzhou Sichuan,646000,P.R.China)
出处
《哈尔滨医药》
2023年第2期130-135,共6页
Harbin Medical Journal
基金
西南医科大学自然科学基金青年项目(2018-ZRQN-122)
四川大学-泸州市人民政府战略合作项目(2019CDLZ-17)。
关键词
整合素
骨关节炎
力学
生物学
Integrin
Osteoarthritis
Mechanics
Biology
