摘要
目的探讨突发性耳聋(SD)患者采用耳后骨膜及鼓室注射甲泼尼龙琥珀酸钠对临床疗效、凝血功能及听力状况的影响。方法选取2020年1月-2021年12月宜春市万载县人民医院收治的SD患者共计68例,按照随机数字表法分成研究组(34例)与对照组(34例),对照组给予地塞米松磷酸钠治疗,研究组给予耳后骨膜及鼓室注射甲泼尼龙琥珀酸钠治疗,比较两组临床疗效、凝血功能、听力状况及不良反应。结果研究组治疗总有效率(91.18%)与对照组(70.59%)相比更高(P<0.05);两组治疗后活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)延长(P<0.05),D-二聚体(D-D)、纤维蛋白原(FIB)水平降低(P<0.05),研究组与对照组相比,APTT、PT更长(P<0.05),D-D、FIB水平更低(P<0.05);两组治疗后500Hz、1000Hz、2000Hz、4000Hz纯音听阈降低(P<0.05),研究组与对照组相比更低(P<0.05);研究组不良反应发生率(2.94%)与对照组(23.53%)相比更低(P<0.05)。结论SD患者耳后骨膜及鼓室注射甲泼尼龙琥珀酸钠能够提高临床疗效,改善患者凝血功能、听力状况,安全性较高。
Objective To explore the effect of methylprednisolone sodium succinate injected into posterior periosteum and tympanum on clinical efficacy,coagulation function and hearing status in patients with sudden deafness(SD).Methods A total of 68 SD patients from January 2020 to December 2021 who were admitted in our hospital were selected,and divided into the study group(34 cases)and the control group(34 cases)by random number table method.The control group was treated with dexamethasone sodium phosphate,and the study group was treated with methylprednisolone sodium succinate injected into the posterior ear periosteum and tympanic cavity.The clinical efficacy,coagulation function,hearing status and adverse reactions of the two groups were compared.Results In comparision of the control group(70.59%),the total effective rate of the study group(91.18%)was higher(P<0.05).After treatment,the activated partial prothrombin time(APTT)and prothrombin time(PT)in both groups were prolonged(P<0.05),the levels of D-dimer(D-D)and fibrinogen(FIB)were decreased(P<0.05),in comparision of the control group,the APTT and PT of the study group were longer(P<0.05),and the levels of D-D and FIB were lower(P<0.05).After treatment,the pure tone hearing threshold of 500Hz,1000Hz,2000Hz,4000Hz in both groups were decreased(P<0.05),and in comparision of the control group,the study group was lower(P<0.05).In comparision of the control group(23.53%),the incidence of adverse reactions in the study group(2.94%)was lower(P<0.05).Conclusion Injection of methylprednisolone sodium succinate into retroauricular periosteum and tympanic cavity of SD patients can improve the clinical efficacy,blood coagulation function and hearing status of patients with high safety.
作者
黄德虎
彭紫辉
Huang Dehu;Peng Zihui(Wanzai County People's Hospital,Yichun,Jiangxi 336100,China)
出处
《首都食品与医药》
2023年第8期63-66,共4页
Capital Food Medicine
关键词
突发性耳聋
耳后骨膜及鼓室注射
甲泼尼龙琥珀酸钠
临床疗效
凝血功能
听力状况
Sudden deafness
Postauricular periosteum and tympanum injection
Methylprednisolone sodium succinate
Clinical efficacy
Coagulation function
Hearing condition
