摘要
目的:探讨降钙素原(PCT)、C反应蛋白(CRP)及血管紧张素Ⅱ(AngⅡ)在老年肺部感染中的诊断价值。方法:选取2020年6月—2022年6月甘肃省康复中心医院收治的80例老年肺部感染患者作为观察组,并选取同期健康体检者40例作为对照组。检测两组PCT、CRP、AngⅡ水平,对观察组疾病严重程度进行评价,并对观察组进行常规治疗。比较对照组体检时与观察组治疗前、治疗3 d、治疗7 d的PCT、CRP、AngⅡ水平。比较观察组不同疾病严重程度患者治疗前PCT、CRP、AngⅡ水平,记录治疗7 d后随访1个月内死亡率。分析PCT、CRP、AngⅡ对老年肺部感染的诊断价值。结果:观察组治疗前、治疗3 d的PCT、CRP及AngⅡ水平均高于对照组体检时,差异有统计学意义(P<0.05)。观察组治疗7 d CRP水平与对照组比较差异无统计学意义(P>0.05),观察组PCT、AngⅡ水平高于对照组,差异有统计学意义(P<0.05)。轻度患者死亡率低于重度患者,轻度患者PCT、CRP水平均低于中度、重度患者,AngⅡ水平低于重度患者,中度患者PCT、CRP、AngⅡ水平均低于重度患者,差异有统计学意义(P<0.05)。PCT诊断老年肺部感染的截断值为0.68 ng/mL,CRP的截断值为15.32 mg/L,AngⅡ的截断值为38.54 ng/L。PCT+CRP+AngⅡ联合诊断老年肺部感染的曲线下面积为(AUC)为0.712,诊断敏感度为85.71%,特异度为66.67%。结论:PCT、CRP及AngⅡ联合诊断老年肺部感染的敏感度和特异度较高,具有较高应用价值。
Objective:To investigate the diagnostic value of procalcitonin(PCT),C-reactive protein(CRP)and angiotensinⅡ(AngⅡ)in pulmonary infection in the elderly.Method:A total of 80 elderly patients with pulmonary infection admitted to Rehabilitation Center Hospital of Gansu Province from June 2020 to June 2022 were selected as the observation group,and 40 physical examiners at the same time were selected as the control group.The levels of PCT,CRP and AngⅡin the two groups were detected.The severity of disease in the observation group was evaluated,and the observation group was given routine treatment.The levels of PCT,CRP and AngⅡwere compared between the control group during physical examination and the observation group before treatment,3 d and 7 d of treatment.The levels of PCT,CRP,AngⅡof patients with different disease severity in the observation group before treatment were compared,and the mortality rate within 1 month was recorded after 7 days of treatment.The diagnostic value of PCT,CRP and AngⅡfor elderly patients with pulmonary infection was analyzed.Result:The levels of PCT,CRP and AngⅡin the observation group before treatment and 3 days of treatment were higher than those in the control group during physical examination,and the differences were statistically significant(P<0.05).There was no significant difference in the level of CRP between the observation group on 7 days of treatment and the control group(P>0.05).The levels of PCT and AngⅡin the observation group on 7 days of treatment were higher than those in the control group,and the differences were statistically significant(P<0.05).The mortality rate of mild patients was lower than that of severe patients,the levels of PCT and CRP in mild patients were lower than those in moderate and severe patients,and the level of AngⅡwas lower than that in severe patients,and the levels of PCT,CRP and AngⅡin moderate patients were lower than those in severe patients,and the differences were statistically significant(P<0.05).The cut-off value of PCT
作者
柳灵
LIU Ling(Rehabilitation Center Hospital of Gansu Province,Lanzhou 730000,China)
出处
《中外医学研究》
2023年第10期82-86,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
甘肃省科技计划项目(18JR3RA081)。
