摘要
原发性胆汁性胆管炎(primary biliary cholangitis,PBC)又名原发性胆汁性肝硬化,是一种由自身免疫介导的慢性肝内胆汁淤积性疾病,多见于中老年女性。胆汁淤积性疾病可继发肝性骨营养不良,以骨质疏松症(osteoporosis,OP)最为突出。PBC患者并发OP可导致骨折风险增加并严重影响患者的生存及生活质量,从而影响疾病的预后。近年来,大量的研究表明,随着PBC的发病率及患病率的上升,OP的发病率及患病率也处于上升趋势。因此,为了改善PBC合并OP患者的生存及生活质量,如何有效的治疗越来越成为人们关注和研究的重点。
Primary biliary cholangitis(PBC),also known as primary biliary cirrhosis,is an autoimmune-mediated chronic intrahepatic cholestatic disease,which is more common in middle-aged and elderly women.Cholestasis can be secondary to hepatic osteodystrophy,with osteoporosis(OP)being the most prominent.OP in PBC patients can increase the risk of fracture and seriously affect the survival and quality of life of patients,thus affecting the prognosis of the disease.In recent years,a large number of studies have shown that with the increase of the incidence and prevalence of PBC,the incidence and prevalence of OP are also on the rise.Therefore,in order to improve the survival and quality of life of patients with PBC combined with OP,how to effectively treat it has become the focus of more and more attention and research.
作者
李虹
赵婕
Li Hong;Zhao Jie(Department of Gastroenterology,Second Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《中国综合临床》
2023年第2期151-156,共6页
Clinical Medicine of China
