摘要
非甾体类抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)在临床应用中常见胃肠道不良反应,其中NSAIDs引起的小肠损伤(NSAIDs-induced small intestinal injuries,NSIs)表现为出现空肠及回肠黏膜红斑、糜烂、溃疡、出血、肠壁穿孔、梗阻等。NSIs的病理机制复杂,且缺乏针对NSIs的有效预防或治疗手段。就近5年关于NSIs病理机制和米索前列醇、黏膜保护剂、抗生素及益生菌、中药及其活性成分、营养补充剂等药物防治NSIs的研究进展进行综述,以期为NSIs的新药研发提供参考和依据。
Nonsteroidal anti-inflammatory drugs(NSAIDs)are clinically used with common gastrointestinal adverse reactions,among which NSAIDs-induced small intestinal injuries(NSIs)are manifested in the appearance of jejunum and ileal mucosa erythema,erosion,ulcer,hemorrhage,intestinal wall perforation and obstruction et al..The pathological mechanisms of NSIs are complex,with a lack of effective prevention or treatment methods.This review summarizes the research progress of the pathological mechanisms of NSIs as well as the prevention and treatment of NSIs by misoprostol,mucosal protective agents,antibiotics and probiotics,traditional Chinese medicines and their active ingredients,nutritional supplements and other drugs in the past five years,in order to provide reference and basis for the research and development of new NSIs drugs.
作者
李雨宸
潘子倩
肖梦雪
张媛媛
LI Yuchen;PAN Ziqian;XIAO Mengxue;ZHANG Yuanyuan(Department of Pharmacology of Chinese Material Medical,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2023年第2期150-158,共9页
Journal of China Pharmaceutical University
关键词
非甾体类抗炎药
小肠损伤
药物防治
nonsteroidal anti-inflammatory drugs
intestinal injury
drug prevention and treatment
