摘要
目的分析血清N末端B型利钠肽原(NT-proBNP)、可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)水平对急性心肌梗死(AMI)患者急诊经皮冠状动脉介入治疗(PCI)近期预后的评估价值。方法本研究为前瞻性研究。抽取2019年1月至2022年1月于新乡市第一人民医院行急诊PCI治疗的80例AMI患者作为研究对象。急诊PCI术后对患者进行跟踪随访,随访时间截止至2022年7月,根据随访期间心脏不良事件发生情况,将患者分为预后不良组和预后良好组。急诊PCI术前检测血清NT-proBNP、sLOX-1等实验室指标,观察血清NT-proBNP、sLOX-1在不同预后患者中的水平变化,分析血清NT-proBNP、sLOX-1水平对AMI患者急诊PCI近期预后的评估价值。结果纳入的80例AMI患者均顺利完成本研究,无退出患者。随访期间,80例行急诊PCI的AMI患者中,预后不良20例,占25.00%。预后不良组血清NT-proBNP、sLOX-1水平高于预后良好组,术后血流TIMI分级中Ⅰ级占比高于预后良好组,差异有统计学意义(P<0.05)。经点二列相关性分析显示,血清NT-proBNP、sLOX-1水平与AMI患者急诊PCI近期预后呈正相关(r>0,P<0.05);绘制受试者工作特征曲线结果显示,血清NT-proBNP、sLOX-1联合评估AMI患者急诊PCI治疗后近期预后的曲线下面积为0.820,高于二者单独评估的0.755、0.730。结论血清NT-proBNP、sLOX-1水平可用于评估AMI患者急诊PCI的近期预后,且二者单独及联合检测对患者近期预后均具有较高的评估价值。
Objective To analyze the value of levels of serum N-terminal B-type natriuretic peptide(NT-proBNP)and soluble lectin like oxidized low density lipoprotein receptor-1(sLOX-1)in evaluating the short-term prognosis of emergency percutaneous coronary intervention(PCI)for acute myocardial infarction(AMI).Methods This study was a prospective study.Eighty patients with AMI who underwent emergency PCI in Xinxiang First People’s Hospital from January 2019 to January 2022 were selected as the study subjects.The patients were followed up after emergency PCI.The follow-up period was up to July 2022.According to the occurrence of cardiac adverse events during the follow-up period,the patients were divided into poor prognosis group and good prognosis group.The levels of serum NT-proBNP and sLOX-1 were detected before emergency PCI,the changes of levels of serum NT-proBNP and sLOX-1 in patients with different prognoses were observed.And the value of serum NT-proBNP and sLOX-1 in evaluation on short-term prognosis of AMI patients after emergency PCI was analyzed.Results All of the 80 patients with AMI successfully completed the study,and no patient withdrew.During the follow-up period,20 of the 80 AMI patients treated by emergency PCI had poor prognosis,accounting for 25.00%.The levels of serum NT-proBNP and sLOX-1 in the poor prognosis group were higher than those in the good prognosis group,and the proportion of postoperative TIMI grade I was higher than that in the good prognosis group(P<0.05).Results of point-biserial correlation analysis showed that serum NT-proBNP and sLOX-1 were positively correlated with the short-term prognosis of AMI patients after emergency PCI(r>0,P<0.05).The result of receiver operating characteristic curve showed that the area under the curve of serum NT-proBNP combined with sLOX-1 in evaluationg the short-term prognosis of AMI patients after emergency PCI treatment was 0.820,which was significantly higher than the 0.755 of NT-proBNP and 0.730 of sLOX-1.Conclusions Serum NT-proBNP and sLOX-1 can
作者
郭辉
Guo Hui(Department of Cardiovascular Medicine,Xinxiang First People’s Hospital,Xinxiang 453000,China)
出处
《中国实用医刊》
2023年第1期31-35,共5页
Chinese Journal of Practical Medicine
