摘要
目的:探讨自制金线莲膏外敷治疗难愈性创面的效果。方法:选取2020年1月至2021年12月该院收治的难愈性创面患者100例,采用掷硬币法分为对照组与观察组,每组50例。对照组患者在清创后采用1%磺胺嘧啶银乳膏外敷治疗,观察组患者在清创后采用自制金线莲膏外敷治疗,两组患者均治疗21 d。比较两组患者的创面愈合率、创面疼痛情况[视觉模拟评分(VAS)]、临床疗效及治疗期间不良反应发生情况。结果:基于广义估计方程分析,治疗14、21 d时,两组患者的创面愈合率较治疗7 d时升高,且观察组患者治疗7、14和21 d时的创面愈合率高于对照组,差异均有统计学意义(P<0.05)。治疗7、14和21 d时,观察组患者创面细菌阳性率低于对照组,差异均有统计学意义(P<0.05)。基于广义估计方程分析,治疗7、14和21 d时,两组患者的VAS评分较治疗前降低,且观察组患者治疗7、14和21 d时的VAS评分低于对照组,差异均有统计学意义(P<0.05)。治疗21 d时,观察组患者临床总有效率为92.00%(46/50),高于对照组的76.00%(38/50),差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:自制金线莲膏外敷治疗难愈性创面患者,可提高临床疗效,促进创面愈合,降低创面细菌检出率,减轻创面疼痛,且安全性较高。
OBJECTIVE:To probe into the effects of self-made Anoectochilus Roxburghii ointment in the treatment of refractory wounds.METHODS:A total of 100 patients with refractory wounds admitted into the hospital from Jan.2020 to Dec.2021 were extracted to be divided into the control group and observation group via the coin tossing method,with 50 cases in each group.The control group was treated with 1%sulfadiazine silver ointment after debridement,while the observation group received self-made Anoectochilus Roxburghii ointment after debridement.Both groups were treated for 21 d.The wound healing rate,wound pain[visual analogue scale(VAS)],clinical efficacy and adverse drug reactions during treatment were compared between two groups.RESULTS:Based on generalized estimation equation,the results showed that at 14 and 21 d after treatment,the wound healing rates in two groups were higher than those at 7 d after treatment,the wound healing rate of the observation group was higher than that of the control group at 7,14 and 21 d after treatment,and the differences were statistically significant(P<0.05).At 7,14 and 21 d after treatment,the positive rate of wound bacteria in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Based on generalized estimation equation,the results showed that at 7,14 and 21 d after treatment,the VAS scores of both groups were lower than those before treatment,the VAS scores of the observation group were lower than those of the control group at 7,14 and 21 d after treatment,with statistically significant differences(P<0.05).At 21 d after treatment,the total clinical effective rate of the observation group was 92.00%(46/50),higher than that 76.00%(38/50)the control group,with statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of adverse drug reactions between two groups(P>0.05).CONCLUSIONS:External application of Anoectochilus Roxburghii ointment can improve the clinical efficacy of
作者
周文涛
王锦
谢恩光
张文仕
彭君强
罗斌
何国
曾婷苑
ZHOU Wentao;WANG Jin;XIE Enguang;ZHANG Wenshi;PENG Junqiang;LUO Bin;HE Guo;ZENG Tingyuan(Dept.of Burn,Plastic and Wound Repair,Meizhou Hospital of Traditional Chinese Medicine,Guangdong Meizhou 514000,China;Dept.of Traditional Chinese Medicine,Meizhou Hospital of Traditional Chinese Medicine,Guangdong Meizhou 514000,China;Dept.of Nursing,Meizhou Hospital of Traditional Chinese Medicine,Guangdong Meizhou 514000,China)
出处
《中国医院用药评价与分析》
2023年第4期438-442,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
广东省中医药局科研项目(No.20201358)。
关键词
难愈性创面
金线莲膏
磺胺嘧啶银乳膏
创面愈合率
创面疼痛
Refractory wounds
Anoectochilus Roxburghii ointment
Sulfadiazine silver ointment
Wound healing rate
Wound pain
