摘要
目的 探讨扩散张量成像(diffusion tensor imaging, DTI)和动脉自旋标记(arterial spin labelling, ASL)联合成像在定量评价不同Fazekas评分脑白质高信号(white matter hyperintensities, WMHs)患者的脑白质隐匿性损伤中的应用价值。材料与方法 对80例WMHs患者和30例健康志愿者行常规MRI、DTI及ASL成像,比较不同Fazekas评分WMHs患者的额叶皮层下、颞叶皮层下、侧脑室前角及三角区、放射冠区及半卵圆中心正常脑白质(normal appearing white matter, NAWM)的成像参数差异。WMHs患者按照Fazekas评分分为三组:A组(0分)、B组(1~3分)和C组(4~6分)。结果 C组较A、B两组双侧侧脑室前角、三角区及放射冠区周围的表观扩散系数(apparent diffusion coefficient, ADC)升高,双侧侧脑室前角及右侧侧脑室三角区周围的各向异性分数(fractional anisotropy, FA)降低,双侧侧脑室三角区及放射冠区周围脑血流量(cerebral blood flow, CBF)降低(P<0.05)。左侧额叶皮层下、右侧放射冠区、右侧半卵圆中心及双侧侧脑室前角、三角区周围NAWM ADC与CBF呈负相关(r=-0.326,-0.21,-0.282,-0.443,-0.429,-0.357,-0.383)。双侧侧脑室前角周围白质FA与CBF呈正相关(r=0.477,0.268)。结论 WMHs评分上升至4~6分时,DTI联合ASL成像可以敏感地反映正常脑白质区域的隐匿性损伤,最敏感区域位于脑室周围的白质区域。
Objective:To investigate the value of diffusion tensor imaging(DTI)and arterial spin labelling(ASL)technique in the quantitative evaluation of occult injury in the white matter regions of white matter hyperintensities(WMHs)patients with different Fazekas scores.Materials and Methods:The routine MRI,DTI and ASL imaging were performed in 80 cases of WMHs and 30 normal subjects.The functional parameters were compared among different Fazekas scores of WMHs in the normal white matter regions in frontal subcortical,temporal subcortical,anterior horn and trigonal of lateral ventricle,corona radiata and centrum semioval.The patients were divided into three groups according to Fazekas score:Group A(0 point),Group B(1-3 points)and Group C(4-6 points).Results:Compared with group A or B,group C had higher apparent diffusion coefficient(ADC)value in bilateral anterior horn of lateral ventricles,trigonal of lateral ventricles and corona radiata regions,and had lower fractional anisotropy(FA)value around bilateral anterior horn of lateral ventricles and trigonal of right lateral ventricle regions(P<0.05).Group C had lower cerebral blood flow(CBF)around bilateral trigonal of lateral ventricles and corona radiata regions(P<0.05).The ADC value were negatively correlated with CBF value in the normal white matter area around left frontal subcortical,right corona radiata,right centrum semiovale,anterior horn of bilateral lateral ventricles and trigonal of bilateral lateral ventricles regions(r=-0.326,-0.21,-0.282,-0.443,-0.429,-0.357,-0.383).There was a positive correlation between FA and CBF in the white matter area around the anterior horn of bilateral lateral ventricles regions(r=0.477,0.268).Conclusions:When the WMHs score ranges 4-6 points,DTI combined with ASL imaging can sensitively identify the occult injury in normal white matter areas.The most sensitive area is located in the normal white matter area around the ventricle.
作者
常晓霞
李相生
蒋瑞静
孙鹏
张金龙
樊红霞
CHANG Xiaoxia;LI Xiangsheng;JIANG Ruijing;SUN Peng;ZHANG Jinlong;FAN Hongxia(Hebei North University,Zhangjiakou 075000,China;Department of Radiology,Air Force Medical Center of Chinese People's Liberation Army,Beijing 100142,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第4期22-28,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
航空医学重大问题科技攻关项目(编号:2020ZTB07)。
