摘要
目的探讨“六君子汤加味”健脾泄浊治疗脾虚湿阻型高尿酸血症的疗效。方法将2018年8月~2020年1月共226例某院门诊收治的脾虚湿阻型高尿酸血症患者随机分为试验组(生活干预+常规西药治疗+口服中药颗粒“六君子汤加味”,每日1剂,2次分服,n=111例)和对照组(生活干预+常规西药治疗,n=115例),治疗周期为12周,观察两组治疗前后中医临床症状、血尿酸、甘油三酯、血清炎症因子水平的变化,比较两组患者生活质量水平和痛风发生情况。结果试验组总有效率明显高于对照组(81.08%vs.65.22%,P<0.01)。治疗后两组血尿酸、甘油三酯、超敏C反应蛋白(hs-CRP)水平较治疗前均明显下降,差异有统计学意义(P<0.01),治疗后两组血尿酸、甘油三酯比较差异无统计学意义(P>0.05),但hs-CRP水平比较差异有统计学意义(P<0.05)。试验组治疗后中医临床症状(脘腹痞闷、腹满、头身困重、口淡不渴、口腻、大便不爽)较治疗前明显下降,差异有统计学意义(P<0.01);对照组治疗后中医临床症状较治疗前均无明显下降,差异无统计学意义(P>0.05)。治疗后两组中医临床症状改善差异有统计学意义(P<0.01)。治疗后试验组患者生活质量综合问卷(GQOLI-74)各维度评分较对照组均明显升高,差异有统计学意义(P<0.05)。治疗结束后1年内,试验组患者痛风发生率较对照组明显降低,差异有统计学意义(14.41%vs.40.87%,P<0.01)。结论“六君子汤加味”口服联合常规生活方式干预治疗可明显降低脾虚湿阻型高尿酸血症患者的血尿酸及甘油三酯水平,相比单纯生活方式干预其能进一步改善脾虚湿阻患者的中医临床症状和生活质量水平,同时降低患者血清炎症细胞因子水平,从而减少痛风的发生。
Objective To explore the effect of"Liujunzi Decoction modified"on hyperuricemia of spleen deficiency and dampness resistance type.Methods From August 2018 to January 2020,226 outpatients with spleen deficiency and dampness resistance hyperuricemia were randomly divided into the test group(life intervention+conventional western medicine treatment+oral traditional Chinese medicine granule"Liujunzi Decoction modified",one dose per day,twice,n=111 cases)and the control group(life intervention+conventional western medicine treatment,n=115 cases).The treatment period was 12 weeks.The clinical symptoms of traditional Chinese medicine,blood uric acid,triglyceride,the level of serum inflammatory factors,the quality of life and the incidence of gout were compared between the two groups.Results The total effective rate of the test group was significantly higher than that of the control group(81.08%vs.65.22%,P<0.01).The levels of serum uric acid,triglyceride and high-sensitivity C-reactive protein(hs-CRP)in the two groups after treatment were significantly lower than those before treatment(P<0.01).The blood uric acid,and triglyceride was no significant difference between the two groups after treatment(P>0.05),but there was significant difference in the level of hs-CRP(P<0.05).After treatment,the clinical symptoms of traditional Chinese medicine(abdominal fullness,abdominal fullness,heavy head and body sleepiness,light and thirsty mouth,greasy mouth and uncomfortable stool)in the test group decreased significantly compared with those before treatment(P<0.01);the clinical symptoms of traditional Chinese medicine in the control group after treatment were not significantly lower than those before treatment,and the difference was not statistically significant(P>0.05).There was significant difference in the improvement of TCM clinical symptoms between the two groups after treatment(P<0.01).After treatment,the scores of all dimensions of GQOLI-74 in the test group were significantly higher than those in the control group(P<0.05).
作者
董霞
王阿芳
梁利娜
邢桂娥
李秀峰
徐磊
张凯贤
魏淑凤
DONG Xia;WANG A-fang;LIANG Li-na(Department of Rheumatology and endocrinology,Fangshan District Hospital of traditional Chinese medicine,Beijing 102400,China)
出处
《中国处方药》
2023年第4期118-122,共5页
Journal of China Prescription Drug
基金
北京中医药科技发展资金项目(JJ2018-16)。
关键词
六君子汤加味
健脾泄浊
脾虚湿阻
高尿酸血症
炎症因子
Liujunzi Decoction modified
Invigorating the spleen and relieving turbidity
Spleen deficiency and dampness resistance
Hyperuricemia
Inflammatory factor
