摘要
目的探究盐酸西替利嗪滴剂联合糠酸莫米松鼻喷雾剂治疗小儿季节性过敏性鼻炎的临床效果。方法选取本院2018年1月至2021年1月收治的196例季节性过敏性鼻炎患儿为研究对象,遵循随机数字法将其分为参照组和研究组,各98例。参照组开展糠酸莫米松鼻喷雾剂治疗,研究组开展盐酸西替利嗪滴剂联合糠酸莫米松鼻喷雾剂治疗。比较两组的治疗效果。结果研究组的治疗总有效率为97.96%,高于参照组的84.69%,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,研究组的超敏C反应蛋白(hs-CRP)、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)水平及嗜酸性粒细胞百分比低于参照组,差异具有统计学意义(P<0.05)。治疗后,研究组的免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平高于参照组,差异具有统计学意义(P<0.05)。结论盐酸西替利嗪滴剂联合糠酸莫米松鼻喷雾剂治疗小儿季节性过敏性鼻炎效果显著,能促进患儿炎症因子、免疫功能指标及嗜酸性粒细胞百分比恢复。
Objective To explore the clinical effect of cetirizine hydrochloride drops combined with mometasone furoate aqueous nasal spray in the treatment of seasonal allergic rhinitis in children.Methods A total of 196 children with seasonal allergic rhinitis admitted in our hospital from January 2018 to January 2021 were selected as the research objects and divided into reference group and study group according to the random number method,with 98 cases in each group.The reference group was treated with mometasone furoate aqueous nasal spray,and the study group was treated with cetirizine hydrochloride drops combined with mometasone furoate aqueous nasal spray.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was 97.96%,which was higher than 84.69%in the reference group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of high sensitivity C-reactive protein(hs-CRP),interleukin-4(IL-4),interleukin-5(IL-5)and eosinophil percentage in the study group were lower than those in the reference group,and the differences were statistically significant(P<0.05).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)in the study group were higher than those in the reference group,and the differences were statistically significant(P<0.05).Conclusion Cetirizine hydrochloride drops combined with mometasone furoate aqueous nasal spray in the treatment of seasonal allergic rhinitis in children has a significant effect,which can promote the recovery of inflammatory factors,immune function indexes and eosinophil percentage in children.
作者
王文娟
张姣
WANG Wenjuan;ZHANG Jiao(Pediatric Respiratory Department,Baoji Maternal and Child Health Care Hospital,Baoji 721000,China)
出处
《临床医学研究与实践》
2023年第13期56-58,共3页
Clinical Research and Practice
关键词
盐酸西替利嗪滴剂
糠酸莫米松鼻喷雾剂
小儿季节性过敏性鼻炎
免疫功能
cetirizine hydrochloride drops
mometasone furoate aqueous nasal spray
seasonal allergic rhinitis in children
immune function
