摘要
Despite the success,it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic therapy.Herein,we report a near-infrared(NIR)/acid-induced nanoplatform based on chitosan(CS)-coated indocyanine green(ICG,photosensitizer)/luteolin(LUT,a natural quorum sensing inhibitor)nanocomposites(ICG/LUT-CS)as antibacterial and antibiofilm agents for skin wound healing.Initially,the ICG/LUT nanoplatforms are prepared by the supercritical antisolvent technology and coated with the CS layer.The obtained ICG/LUT-CS with ultra-high encapsulation efficiency exhibited more favorable photothermal conversion effects and improved NIR laser/acid dual-induced drug release behavior than individual modalities,achieving exceptional bacteria-killing and biofilm elimination effects.Moreover,the ICG/LUT-CS realized the synergetic effects of chemotherapy and photothermal therapy outcomes for wound healing.Together,our findings provided an appealing strategy for the rapid preparation and future translational application of ICG/LUT-CS as an ideal agent for fighting against biofilm infections.
基金
supported by the National Key Research&Development Program of China(2019YFE0113600)
the National Natural Science Foundation of China(NSFC 81971734,32071323)
and Program for Innovative Research Team in Science,Scientific Research Funds of Huaqiao University(21BS113).
