摘要
迄今为止,研究人员已发现21种S100蛋白家族成员,尽管它们在结构上高度相似,但其功能却各不相同,如能够对细胞内Ca^(2+)水平和细胞外环境的变化产生独特的适应性反应。作为S100蛋白家族的一员,S100A16位于人染色体1q21中的S100A基因簇,是从星形细胞瘤中分离出来的一种新型E-F hand蛋白,也是一种新型的促脂肪生成因子。目前对S100A16在脂代谢中的直接相关性研究并不多。本文对相关文献进行回顾,综述了S100A16在脂肪生成和脂质代谢过程中的重要作用,为该领域的后续研究提供参考。
To date,researchers have found 21 members of the S100 protein family.Despite their high structural similarity,they function differently,such as being able to produce unique adaptive responses to changes in intracellular Ca^(2+) levels and the extracellular environment.As a member of the S100 protein family,S100A16,which is located in the S100A gene cluster in human chromosome 1q21,is a novel E-F hand protein isolated from astrocytomas and a novel proadipogenic factor.At present,there are few studies on the direct correlation of S100A16 in lipid metabolism.This article reviews the relevant literature and summarizes the important role of S100A16 in the process of lipogenesis and lipid metabolism,so as to provide reference for subsequent research in this field.
作者
叶瑞芳
黄彩玲(综述)
孙艳芹(审校)
YE Rui-fang;HUANG Cai-ling;SUN Yan-qin(The First Clinical Medical College of Guangdong Medical University,Zhanjiang 524000,Guangdong,CHINA;Department of Pathology,Basic Medical College of Guangdong Medical University,Zhanjiang 524000,Guangdong,CHINA)
出处
《海南医学》
CAS
2023年第8期1187-1189,共3页
Hainan Medical Journal
基金
广东省基础与应用基础研究基金项目(编号:2021B1515140067、2022A1515012190)
广东省医学科研基金项目(编号:A2022019)
大学生创新创业训练计划项目(编号:202210571036、S202210571082)
广东省湛江市科技发展专项资金竞争性分配项目(编号:2022A01018)。
