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晚期非小细胞肺癌MET 14外显子跳跃突变的治疗新进展 被引量:1

New advances in the treatment of MET 14 exon skipping mutation in advanced non⁃small cell lung cancer
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摘要 间充质-上皮转化因子(mesenchymal-epithelial transition factor,MET)14外显子跳跃突变是非小细胞肺癌(non-small cell lung cancer,NSCLC)中继表皮生长因子受体(epidermal growth factor receptor,EGFR)、KRAS、间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)后第4个最常见的独立致癌因素,同样也是NSCLC患者的独立预后因素。随着克唑替尼、卡马替尼、特泊替尼及沃利替尼等MET-酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)接连获批,MET靶向治疗得到有效进展。本文就MET 14外显子跳跃突变的NSCLC患者治疗研究进展进行综述。
作者 孙曼 李晓敏 SUN Man;LI Xiaomin
出处 《中国癌症防治杂志》 CAS 2023年第2期239-244,共6页 CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
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